نتایج جستجو برای: piperidines
تعداد نتایج: 269 فیلتر نتایج به سال:
σ2-Agonist 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (7, PB 28), which proved to revert doxorubicin resistance in breast cancer cells, was taken as a template to prepare new analogs. One of the two basic N-atoms was alternatively replaced by amethine or converted into an amide or ammonium function, with the aim of finding out which of themwas essential for...
available and the reaction has the potential for the simultaneous creation of multiple stereocenters. Here we describe an efficient and unprecedented auxiliary-based method for the asymmetric hydrogenation of substituted pyridines (YR= N), which enables the stereoselective formation of piperidines with up to four new chiral centers in a single operation (Scheme 2a). The heterogeneous catalytic ...
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