The aim of the present study was to characterize the type(s) of NaPO4 cotransporter expressed in the human renal cell line HEK-293 and its regulation by parathyroid hormone (PTH) in wild-type cells and in cells transfected by the PTH/PTH-related protein (PTHrP) receptor. The results showed that human embryonic kidney HEK-293 cells expressed NaPO4 cotransporter type III (PiT1) mRNA and protein. ...

BACKGROUND Chronic peritoneal dialysis (PD) is associated with peritoneal calcification. Studies in vascular tissue suggest that ectopic calcification is not merely a passive but a regulated process resembling bone mineralization. We investigated whether peritoneal calcification is controlled by matrix Gla protein (MGP) secreted by peritoneal mesothelial cells. METHODS Human primary mesotheli...

Afferent connections to the sensory inner (IHCs) and outer hair cells (OHCs) in the cochlea refine and functionally mature during the thyroid hormone (TH)-critical period of inner ear development that occurs perinatally in rodents. In this study, we investigated the effects of hypothyroidism on afferent type II innervation to outer hair cells using the Snell dwarf mouse (Pit1(dw)). Using a tran...

many factors including genetic, environmental, and acquired are involved in breast cancer development across various societies. among all of these factors in families with a history of breast cancer throughout several generations, genetics, like predisposing genes to develop this disease, should be considered more. early detection of mutation carriers in these genes, in turn, can play an import...

Background: Fibrin(ogen) maintains inflammation in various disorders but has never been linked to cartilage damage rheumatoid arthritis (RA) or other forms of inflammatory arthritis. Objectives: To investigate the role fibrin deposition on integrity Methods: Fibrin knee was analyzed by immunohistochemistry RA patients and murine adjuvant-induced (AIA). In chondrocytes, fibrinogen expression ( F...

Pituitary neuroendocrine tumors (PitNET) are originating from adenohypophyseal cells. Although benign, PitNETs sometimes exhibit aggressive biological behavior that was the inspiration for change of old and traditional name "pituitary adenomas". Current standard in PitNET diagnostics, according to WHO criteria, is immunohistochemistry, with application antibodies adenohypophysis hormones transc...