Background Dietary treatment containing fiber-rich foods may contribute to lowering weight in obese women. Objective To investigate the effect of a hypoenergetic diet combined with pumpkin seed flour (PSF) consumption on quality, anthropometric indices, and glucose lipid metabolism Methods We conducted randomized, double-blind, placebo-controlled, 90-day clinical trial women, distributed into f...

background complications and postoperative pain are major care problems that can affect the quality of health care plan. objectives according to the use of multimodal therapy the current study aimed to compare the efficacy of gabapentin and celecoxib in pain management and complications after laminectomy at ilam university of medical sciences, ilam, iran, in 2015. patients and methods in this r...

Obesity-induced inflammation plays a substantial role in the development of insulin resistance and type 2 diabetes. The altered gut flora obesity can also contribute to metabolic dysregulation systemic inflammation. However, it remains unclear how affects microbiome. We hypothesized that colchicine’s anti-inflammatory effects would be associated with improvements microbial diversity. conducted ...

In the phase 2 CELEST study, positive efficacy results were obtained with Janus kinase 1 inhibitor upadacitinib for adult patients moderate to severe Crohn’s disease. We present health-related quality of life and work productivity improvement from CELEST. (NCT02365649) was a double-blind study where randomized 1:1:1:1:1:1 in 16-week induction period placebo or 3 mg twice daily (BID), 6 BID, 12 ...

OBJECTIVE The aim of this study was to investigate the efficacy and safety imeglimin, first in a new class oral antidiabetic agent, Japanese patients with type 2 diabetes. RESEARCH DESIGN AND METHODS This double-blind, randomized, parallel-group, placebo-controlled phase 3 trial 30 sites Japan. Eligible participants were individuals aged ?20 years diabetes treated diet exercise, stable for ?12 ...

Objective: There are some studies about the good effects of herbal medicine on blood glucose. This study was designed to evaluate the synergism effect of Peganum Harmala (P.harmala), Quercus Infectoria (Q.i), Vaccinium Myrtillus (V.myrtillus), Citrullos Colocynthis (C.colocynthis), Securigera Securidaca (S.s) on blood glucosein type 2 diabetic patients. Materials and Methods: Twenty four type ...

Objective Antidepressants outperform placebo with an effect size of around 0.30. It has been suggested that sizes as high 0.875 are necessary for a minimal clinically important difference. Whether such achievable in placebo-controlled trials is unknown. Therefore, we aimed to assess what theoretically antidepressants. Methods Patient-level analyses comparing Hamilton Depression Rating Scale (HD...