Nine phenolic compounds isolated from Cratoxylum maingayi and C. cochinchinense were evaluated for anti-malarial activity against Plasmodium falciparum, and for cytotoxic activity against the NCI-H187 (human small cell lung cancer) cancer cell line. Formoxanthone C (3) was found to be the most active against the NCI-H187 cancer cell line, with an IC(50) of 0.22 microg/mL, while vismione B (7) h...

In this investigation, we have measured the invasion and growth of the malaria parasite Plasmodium falciparum into elliptocytic red blood cells (RBCs) obtained from subjects with homozygous hereditary elliptocytosis. These elliptocytic RBCs have been previously characterized to possess molecular defects in protein 4.1 and glycophorin C. Our results show that the invasion of Plasmodium falciparu...

A series of new aculeatin-like analogues were synthesized in two steps by combining two sets of building blocks. Many compounds showed inhibitory activities in vitro against Plasmodium falciparum and have helped to gain more insight into structure-activity relationships around the spirocyclohexadienone pharmacophoric scaffold. Plasmodium falciparum thioredoxin reductase (PfTrxR) has been invest...

Glomerulonephritis occurs as a rare form of renal manifestation in Plasmodium falciparum malaria. Herein, we report a case of falciparum malaria-associated IgA nephropathy for the first time. A 49-yr old male who had been to East Africa was diagnosed with Plasmodium falciparum malaria. Microhematuria and proteinuria along with acute kidney injury developed during the course of the disease. Kidn...

The issue of whether the malaria parasite Plasmodium falciparum is effectively clonal, as some argue, or undergoes outcrossing at a high rate, as many others believe, has been controversial. Recent data support the latter view, though no doubt the puzzle has not yet been laid to rest.

Type I signal peptidases are important membrane-bound serine proteases responsible for the cleavage of the signal peptide of the proteins. These enzymes are unique serine proteases that carry out catalysis using a serine/lysine catalytic dyad. In the present study, we report the isolation of type I signal peptidase from the malaria parasites Plasmodium falciparum, Plasmodium knowlesi, and Plasm...

OBJECTIVE To screen the antimalarial compounds of daphnetin derivatives against Plasmodium falciparum in vitro. METHOD Plasmodium faciparum (FCC1) was cultured in vitro by a modified method of Trager and Jensen. Antimalarial compounds were screened by microscopy-based assay and microfluorimetric method. RESULTS DA79 and DA78 showed potent antimalarial activity against Plasmodium falciparum ...

Malaria is one of the most common causes of febrile illness in travelers. Coinfections with bacterial, viral, and fungal pathogens may not be suspected unless a patient fails to respond to malaria treatment. Using novel immunohistochemical and molecular techniques, Plasmodium falciparum, Clostridium perfringens, and Candida spp. coinfections were confirmed in a German traveler to Haiti. Plasmod...

Diagnosis of malaria is a fundamental component case management. Parasitological confirmation before treatment was recommended for endemic countries. Microscopy diagnosis malaria, the gold standard as constraints such as: level expertise, quality equipment and reagents may lead to misdiagnosis. The histidine rich protein 2 (HRP-2) based rapid diagnostic test (RDT) detects Plasmodium falcipa...

The human malaria parasite Plasmodium falciparum represses transcription of the gene encoding AP2-G, which is master regulator germ cell differentiation, via heterochromatin condensation following histone H3 lysine 9 trimethylation (H3K9me3). Although H3K9me3-marked typically constitutive and its establishment depends on RNA interference (RNAi) pathway in fission yeast centromeres, parasites la...