Nanoparticles (NPs) are commonly used, and concerns about their possible adverse effects are being voiced as well. However, little is known about the fates of NPs released to the environment. The aim of the study was to (i) evaluate the ability of Sinapis alba and Lepidium sativum plants to take up platinum nanoparticles (Pt-NPs) and translocate them to aboveground organs, (ii) compare the accu...

Platinum compounds represent one of the great success stories of metals in medicine. Following the serendipitous discovery of the anticancer activity of cisplatin by Rosenberg, a large number of cisplatin variants have been prepared and tested for their ability to kill cancer cells and inhibit tumor growth. These efforts continue today with increased realization that new strategies are needed t...

Imaging mass cytometry was used for direct visualization of platinum localization in tissue sections from tumor and normal tissues of cisplatin-treated mice bearing pancreas cancer patient-derived xenografts. This recently-developed technology enabled simultaneous detection of multiple markers to define cell lineage, DNA damage response, cell proliferation and functional state, providing a high...

Conformal deposition of platinum as ultrathin shells on facet-controlled palladium nanocrystals offers a great opportunity to enhance the catalytic performance while reducing its loading. Here we report such a system based on palladium icosahedra. Owing to lateral confinement imposed by twin boundaries and thus vertical relaxation only, the platinum overlayers evolve into a corrugated structure...

We present a novel fabrication route yielding highly active platinum anodes for body implantable glucose micro fuel cells. Such devices harvest electrical energy from glucose and oxygen in body fluids and are currently under development as sustainable power supply for medical implants. The novel anode fabrication process roots on the interdiffusion of an extractable non-noble metal with bulk pl...

1. THE CASE OF " BRAIN PLATINUM " It is widely believed that marketing can bring premium returns to an enterprise: therefore, people are likely to attribute a business success to its marketing strategies. However, the case of Brain Platinum is a puzzle to many as its advertisement has been considered to be vulgar by the public and lots of professionals in the advertising industry, and yet it is...

Platinum therapies For half a century, the field of metalbased anticancer drugs has been dominated by the precious metal platinum. The discovery of platinum’s anticancer properties was made by chance during an experiment in 1965, conducted at Michigan State University by Barnett Rosenberg. Rosenberg used a platinum electrode to apply an electric field to a colony of E. coli, which was observed ...

OBJECTIVE Isotope ratio mass spectrometry of hydrogen and oxygen is frequently used to determine total energy expenditure (TEE) using doubly labeled water. Conventionally, hydrogen isotope ratio is determined in hydrogen gas generated from water samples using zinc reduction. We compare this with a new automated platinum method to determine the ratios of hydrogen isotopes in deuterium-enriched w...

We undertook a systematic review of the pre-clinical and clinical literature for studies investigating the relationship between platinum and taxane resistance. Medline was searched for (1) cell models of acquired drug resistance reporting platinum and taxane sensitivities and (2) clinical trials of platinum or taxane salvage therapy in ovarian cancer. One hundred and thirty-seven models of acqu...

Despite the high objective response rate (70–80%) of advanced epithelial ovarian cancer to platinum-/taxane-based chemotherapy the majority of patients treated for this condition ultimately experience recurrence of the disease process [1–3]. At the time of documented progression of the malignancy, these individuals are candidates to receive a second-line management strategy. It is well recogniz...