Platinum resistance has long been a major issue in the treatment of various cancers. We previously reported that enhanced annexin A4 (ANXA4) expression, a Ca2+-regulated phospholipid-binding protein, induces chemoresistance to platinum-based drugs. In this study, we investigated the role of annexin repeats, a conserved structure of all the annexin family, responsible for platinum-resistance as ...

Platinum based drugs are the cornerstone of chemotherapy for ovarian cancer, however the development of chemoresistance hinders its success. IL-8 is involved in regulating several pro-survival pathways in cancer. We studied the expression of IL-8 and IL-8 receptors in platinum sensitive and resistant cell lines. Using qRT-PCR and immunohistochemistry, both platinum sensitive (PEA1, PEO14) and r...

Platinum is recognized as a harmless metal and is widely used in many industrial products. Recent studies have proposed that platinum in the form of nanoparticles has antioxidant properties, suggesting potential uses for platinum nanoparticles as additives in foods and cosmetics, with direct exposure consequences for humans. However, the influence of platinum nanoparticles on humans has not bee...

A platinum(II) complex with the antiviral drug acyclovir was synthesized and its antiviral and anticancer properties were investigated in comparison to those of acyclovir and cisplatin. The platinum-acyclovir complex maintained the antiviral activity of the parent drug acyclovir, though showing a minor efficacy on a molar basis (ID(50) = 7.85 and 1.02 muMu for platinum-acyclovir and cisplatin, ...

ABSTRACT- To study the effect of tree roots on increasing water infiltration in soil and also to determine and assess the coefficients of different infiltration models, some infiltration tests were performed in three tree plantation areas in Badjgah, Fars province with different soil textures (clay loam for pear plantation, sandy loam for grape plantation, loamy sand for pine trees). In each pl...

a 47 year-old female died after mitral valve replacement. post-cardiopulmonary bypass right ventricle was not able to pump despite good left ventricular contractility. at microscopic examination, diffuse right ventricular fatty infiltration was found. we found no previous report of this pathology in patients with mitral stenosis

the intraoperative care of pheochromocytomas can be difficult and lead to serious complications. we present a case of a 46 year-old female undergoing laparoscopic resection of pheochromocytoma, who was scheduled for surgery with phenoxybenzamine and amlodipin. under general anesthesia cardiovascular stability was achieved by peritumoral infiltration of lidocaine during resection.

study of the spatial variability of infiltration characteristics is essential to estimating infiltration parameters on a local scale. the objectives of the present study were to scale the parameters of a philip two-term model for infiltration and survey the variability of infiltration characteristics geostatistically using wastewater in the bajgah catchment. infiltration was measured at 30 poin...

the microbial fuel cells (mfcs) are a kind of systems through which the anaerobic bacteriaalong with the oxidation of simple or complicated organic matter in the wastewater can generate the electricpower. this is a modern approach used in generation of the clean and renewable energy. in this research, two pilot laboratories of double-chamber microbial fuel cells were made. one of them contained...