BACKGROUND Ovarian cancer remains an on-going challenge mainly due to the development of drug resistance and also because the cancer is likely to have metastasized at the time of diagnosis. Currently, chemotherapy based on platinum drugs such as cisplatin is the primary treatment for the disease. Copper transporter 1 is involved in the transport of cisplatin into the cell, but is also down-regu...

Although epithelial ovarian cancers (EOCs) are initially treated with platinum-based chemotherapy, EOCs vary in platinum responsiveness. Cataloging antineoplastic agents according to their effectiveness against platinum-resistant and platinum-sensitive EOC cell lines is valuable for development of therapeutic strategies to avoid platinum inefficacy and to exploit platinum sensitivity. TOV-21G d...

Platinum resistance is a critical barrier for clinicians to improve the survival of ovarian cancer. Our study evaluated the correlation between copy number variations (CNVs) of neurotrophic tyrosine receptor kinase 3 (NTRK3) and the prognosis of ovarian cancer, which might predict platinum resistance in ovarian cancer patients.Array comparative genomic hybridization (CGH) was used to test gene ...

Static energy minimization and Monte Carlo simulation are used to study the effect of external electrostatic fields on the structure of a self−assembled monolayer (SAM) formed by methoxy tri(ethylene glycol) terminated alkanethiol molecules. It is found that fields of the order of 1 V/Å in strength can substantially change the equilibrium configuration of the SAM, making the oxygen atoms of the...

This paper describes a physical-organic study of the effect of uncharged, polar, functional groups on the rate of charge transport by tunneling across selfassembled monolayer (SAM)-based large-area junctions of the form AgS(CH2)nM(CH2)mT//Ga2O3/EGaIn. Here Ag is a template-stripped silver substrate, -Mand -T are “middle” and “terminal” functional groups, and EGaIn is eutectic gallium−indium all...

background: rad51 is a protein with critical role in double strand break repair. down-regulation of this protein has a significant effect in radiosensitivity of some cell lines like prostate carcinoma. compared to monolayer cell culture model, the spheroids are more resistant to radiation. the aim of the current study was to determine the rad51 protein level in du145 spheroids, and monolayer ce...

Platinum is ubiquitous in the production sectors of chemicals and fuels; however, its scarcity in nature and high price will limit future proliferation of platinum-catalysed reactions. One promising approach to conserve platinum involves understanding the smallest number of platinum atoms needed to catalyse a reaction, then designing catalysts with the minimal platinum ensembles. Here we design...

Acquisition of platinum resistance following first line platinum/taxane therapy is commonly observed in ovarian cancer patients and prevents clinical effectiveness. There are few options to prevent platinum resistance; however, demethylating agents have been shown to resensitize patients to platinum therapy thereby demonstrating that DNA methylation is a critical contributor to the development ...

in this study, polystyrene ethylene butylene polystyrene (psebs) was functionalized to prepare mono and bipolar ion exchange membranes. in the case of the bipolar membrane, platinum was used as the intermediate layer. nacl solution of concentration ranging from 5 g/l to 25 g/l was used as the feed solution. a commercially procured ion exchange membrane made of polystyrene divinyl benzene was al...