Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is often caused by maternal alloantibodies against the human platelet antigen (HPA)-1a, which opsonizes fetal platelets (PLTs). Subsequent PLT destruction is mediated via the Fc part of the alloantibodies. The monoclonal antibody (mAb) SZ21 binds to the HPA-1a epitope and inhibits the binding of maternal alloantibodies. However, it also promote...

Pak J Med Sci 2015 Vol. 31 No. 3 www.pjms.com.pk 745 We read with great interest the article “Can mean platelet volume and platelet distrubition width be possible markers for ectopic pregnancy and tubal rupture?” by Ulkumen et al. in Pakistan Journal of Medical Sciences.1 We appreciate the authors for their study. We wanted to contribute to this study as it was related to our article: “The effi...

AIM OF THE STUDY Studies about possible risks connected with β-emitterradiotherapy concentrate mainly on potential myelotoxicity. Results of previously published analysis based on white blood cells (WBC) and platelet (PLT) counts - before and after radionuclide treatment - are quite varied. The aim of our study was to present the greatest possible impact of Samarium-153 on bone marrow function ...

We determined the complete nucleotide sequence of the toxB gene (375 base pairs in length), which encodes the B subunit of heat-labile enterotoxin produced from Escherichia coli pathogenic for humans (hLT). The amino acid sequence of the B subunit of hLT was deduced from the nucleotide sequence. Consequently, it has become possible to study the homology between the B subunits of three similar t...

Hamid Nasri1 Azar Baradaran2 End-stage renal failure often is associated with abnormal bleeding that may represent an important complication of this disorder. The hemorrhagic tendency currently is attributed to altered primary hemostasis, mainly platelet dysfunction. The aim of the present study was to elucidate whether and how in patients, with uremia on hemodialysis, the level of plasma HCO3 ...

The effects of gel-filtered platelets on euglobulin clot lysis time (ECLT) were analyzed to elucidate the possible role of platelets in thrombolysis. Gel-filtered platelet-supplemented ECLT (plt-ECLT) was significantly shorter than ECLT without platelets (regular ECLT). Abciximab, anti-glycoprotein IIb/IIIa (GPIIb/IIIa) antibody, and cytochalasin B nullified the enhancement of ECLT by platelets...

Let $X$ be a generic determinantal affine variety over perfect field of characteristic $p \geq 0$ and $P \subset X$ standard prime divisor generator $\mathrm{Cl}(X) \cong \mathbb{Z}$. We prove that the pair $(X,P)$ is purely $F$-regular if $p>0$ so log terminal (PLT) $p=0$ $\mathbb{Q}$-Gorenstein. In general, using recent results Z. Zhuang S. Lyu, we show PLT-type, i.e. there $\mathbb{Q}$-divis...

BACKGROUND Salvage liver transplantation (SLT) has been reported as being feasible for patients who develop recurrent hepatocellular carcinoma (HCC) after primary liver resection, but this finding remains controversial. We retrospectively studied the clinical characteristics of SLT recipients and conducted a comparison between SLT recipients and primary liver transplantation (PLT) recipients. ...

INTRODUCTION Platelet-derived growth factor (PDGF) and P-selectin, the low-molecular weight proteins located mainly in the platelet alpha-granules, are considered to be biologically active markers of platelet (PLT) activation. OBJECTIVES The study objective was to assess levels of PDGF-AB and sP-selectin in relation to PLT blood count in patients with colorectal cancer (CRC) who were examined...

T cell homing to peripheral lymph nodes (PLNs) is defined by a multistep sequence of interactions between lymphocytes and endothelial cells in high endothelial venules (HEVs). After initial tethering and rolling via L-selectin, firm adhesion of T cells requires rapid upregulation of lymphocyte function-associated antigen 1 (LFA-1) adhesiveness by a previously unknown pathway that activates a Ga...