نتایج جستجو برای: pml

تعداد نتایج: 3358  

Journal: :Journal of cell science 2011
Delphine Cuchet Amanda Sykes Armel Nicolas Anne Orr Jill Murray Hüseyin Sirma Joerg Heeren Alexander Bartelt Roger D Everett

Intrinsic antiviral resistance mediated by constitutively expressed cellular proteins is one arm of defence against virus infection. Promyelocytic leukaemia nuclear bodies (PML-NBs, also known as ND10) contribute to host restriction of herpes simplex virus type 1 (HSV-1) replication via mechanisms that are counteracted by viral regulatory protein ICP0. ND10 assembly is dependent on PML, which c...

Journal: :Journal of virology 2012
Nirojini Sivachandran Christopher W Dawson Lawrence S Young Fei-Fei Liu Jaap Middeldorp Lori Frappier

Approximately 10% of gastric carcinomas (GC) are comprised of cells latently infected with Epstein-Barr virus (EBV); however, the mechanism by which EBV contributes to the development of this malignancy is unclear. We have investigated the cellular effects of the only EBV nuclear protein expressed in GC, EBNA1, focusing on promyelocytic leukemia (PML) nuclear bodies (NBs), which play important ...

2010
Yang Shen

The complex-frequency-shifted perfectly matched layer CFS-PML technique can efficiently absorb near-grazing incident waves. In seismic wave modeling, CFS-PML has been implemented by the first-order-accuracy convolutional PML technique or second-order-accuracy recursive convolution PML technique. Both use different algorithms than the numerical scheme for the interior domain to update auxiliary ...

Journal: :Molecular cancer research : MCR 2009
Yih-Lin Chung Tzung-Yuan Tsai

The mechanism responsible for hepatitis B virus (HBV) exacerbation during chemotherapy and radiotherapy remains unknown. We investigated whether the activation of DNA repair pathways influences HBV replication. The upregulation of the promyelocytic leukemia (PML) protein and its associated PML nuclear body (PML-NB) by chemotherapy and irradiation-induced DNA repair signaling correlated with the...

Journal: :Blood 1995
L Flenghi M Fagioli L Tomassoni S Pileri M Gambacorta R Pacini F Grignani T Casini P F Ferrucci M F Martelli

PG-M3 is a new monoclonal antibody (MoAb) specifically directed against a peptide sequence located in the aminoterminal region of the human PML protein. PML gene fuses with the retinoic acid receptor alpha (RAR alpha) gene during the t(15; 17) chromosomal translocation of acute promyelocytic leukemia (APL). The epitope recognized by PG-M3 is species-specific and fixative-resistant and is shared...

Journal: :Journal of virology 1998
K L Borden E J Campbell Dwyer M S Salvato

The promyelocytic leukemia protein (PML) forms nuclear bodies which are altered in some disease conditions. We report that the cytoplasmic RNA virus lymphocytic choriomeningitis virus (LCMV) influences the distribution of PML bodies. In cells infected with LCMV, the Z protein and PML form large bodies primarily in the cytoplasm. Transient transfection studies indicate that Z alone is sufficient...

2014
Miles C. Smith Andrew C. Box Jeffrey S. Haug William S. Lane David J. Davido

Herpes simplex virus type 1 (HSV-1) is a significant human pathogen that infects a large portion of the human population. Cells deploy a variety of defenses to limit the extent to which the virus can replicate. One such factor is the promyelocytic leukemia (PML) protein, the nucleating and organizing factor of nuclear domain 10 (ND10). PML responds to a number of stimuli and is implicated in in...

Journal: :Blood 2004
Carmela Gurrieri Khedoudja Nafa Taha Merghoub Rosa Bernardi Paola Capodieci Andrea Biondi Stephen Nimer Dan Douer Carlos Cordon-Cardo Robert Gallagher Pier Paolo Pandolfi

The promyelocytic leukemia (PML) tumor suppressor of acute promyelocytic leukemia (APL) is essential for a number of proapoptotic and growth-suppressive pathways as well as for the activity of differentiating agents such as retinoic acid (RA). In human APL, the dose of PML is reduced to heterozygosity given that one allele is involved in the chromosomal translocation while the status of the rem...

Journal: :Journal of cell science 2005
Reagan W Ching Graham Dellaire Christopher H Eskiw David P Bazett-Jones

Promyelocytic leukemia (PML) bodies have been implicated in a variety of cellular processes, such as cell-cycle regulation, apoptosis, proteolysis, tumor suppression, DNA repair and transcription. Despite this, the function of PML bodies is still unknown. Direct and indirect evidence supports the hypothesis that PML bodies interact with specific genes or genomic loci. This includes the finding ...

Journal: :Journal of neurology, neurosurgery, and psychiatry 2012
Dirk Mentzer Jürgen Prestel Ortwin Adams Ralf Gold Hans-Peter Hartung Hartmut Hengel Bernd C Kieseier Wolf-Dieter Ludwig Brigitte Keller-Stanislawski

BACKGROUND Novel immunosuppressive/modulating therapies with monoclonal antibodies (MABs) have been associated with progressive multifocal leukoencephalopathy (PML), a potentially fatal disease of the brain caused by the JC virus. Taking the complex diagnostic testing and heterogeneous clinical presentation of PML into account, an agreed case definition for PML is a prerequisite for a thorough ...

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