نتایج جستجو برای: poikiloderma
تعداد نتایج: 174 فیلتر نتایج به سال:
Breast Cancer (BC) has associated risk factors and genetic factors like BRCA1, and BRCA2. Many benign and malignant disease processes are found concurrently with BC and believed to be additional risk factors like gall bladder stones (cholelithiasis), hypertension, diabetes mellitus, cerebrovascular lesions, arthritis, spine and spinal cord degenerative lesions, infertility, depression, sleep di...
OBJECTIVE To investigate the clinical, genetic, and laboratory features of 26 patients with Kindler syndrome. DESIGN Case series of patients recruited when they were seen at outpatient consultations in the Department of Dermatology at the Changuinola Hospital in Bocas del Toro, Panama, between May 1986 and December 1990. SETTING Clinical history, physical examination, and laboratory studies...
Dyskeratosis congenita is a highly pleotropic genetic disorder. This heterogeneity can lead to difficulties in making an accurate diagnosis and delays in appropriate management. The aim of this study was to determine the underlying genetic basis in patients presenting with features of dyskeratosis congenita and who were negative for mutations in the classical dyskeratosis congenita genes. By wh...
Themechanism for voriconazole-induced photosensitivity andphototoxicity remainsunknown.One current hypothesis includes a potentially phototoxic UV-B–absorbing N-oxide metabolite of voriconazole.4 Alternatively, inhibition of CYP450 with voriconazole therapy is thought to possibly increase serum retinol level, a known photosensitizer.5 Malignant skin conditions associated with chronic voriconazo...
BACKGROUND The lack of standardization of clinical diagnostic criteria, classification and severity scores of chronic graft-versus-host disease led the National Institutes of Health to propose consensus criteria for the purpose of clinical trials. METHOD Here we describe a one-day workshop model conducted by the Chronic Graft-versus-Host Disease Brazil-Seattle Consortium Study Group to train ...
Sir, We report a 47-year-old man with light brown macular pigmentation on the nape of his neck (Fig. 1). It was asymptomatic and had developed gradually over 2 years. He worked outdoors as a pipe fitter on an oilrig module; however, he denied exposure at this site because he always wore a shirt with a collar that covered the affected area. However, on further questioning it transpired that he s...
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