AIM To investigate the effect of oral administration of camel milk on liver enzymes, total proteins and histology of poloxamer 407 induced hyperlipidaemic wistar rats. MATERIAL AND METHODS Thirty male wistar rats weighing between 150-200 g were randomly assigned into six groups of five each; group I: administered distilled water, group II: induced with P407, group III: induced with P407 and t...

Fungal infections of skin and/or nails are common diseases resulting in major challenges in topical treatment. Therefore, the objective of the present study was to develop a dermal formulation targeting both tinea pedis and onychomycosis. The antifungal agent ciclopirox olamine (CPX) was incorporated into a variety of poloxamer 407-based formulations and analysed regarding its in vitro permeati...

Ursolic acid is a promising candidate for treatment of Chagas disease; however it has low aqueous solubility and intestinal absorption, which are both limiting factors for bioavailability. Among the strategies to enhance the solubility and dissolution of lipophilic drugs, solid dispersions are growing in popularity. In this study, we employed a mixture of the surfactants poloxamer 407 with sodi...

The objective of the present study was to determine the effect of different ratios of monoolein and oleic acid on in vitro release and skin permeation of tacrolimus from monoolein-based liquid crystalline nanoparticles. The nanoparticles were prepared by sonicating a mixture of melted monoolein, poloxamer 407, oleic acid and tacrolimus to which distilled water was added. Formation of cubosomes ...

The present study describes the preparation and evaluation of a poloxamer 407 (P407)-based thermoreversible gel using Carbopol 934P (C934P) as a mucoadhesive polymer and hydroxypropyl-β-cyclodextrin (HP-β-CD) for enhancing the aqueous solubility and intranasal absorption of fexofenadine hydrochloride (FXD HCl). The prepared gels were characterized by gelation temperature, viscoelasticity, and d...

OBJECT The surfactant, poloxamer 188 (P-188), has been found to protect against tissue injury in various experimental models. Its protective mechanism may involve the effects of the surfactant against oxidative stress and inflammation. The authors investigated the role of P- 188 in the reduction of tissue injury and macrophage response in a model of excitotoxic brain injury in the rat striatum....

the present study investigates the possibility of using poloxamers as solubility and dissolution rate enhancing agents of poorly water soluble bioactive constituent patchouli alcohol (pa) that can be used for the preparation of immediate release pellets formulation. two commercially available grades poloxamer 188 (p 188) and poloxamer 407 (p 407) were selected, and solid dispersions (sds) conta...