Hydrophilic polymers, both surfactants and triblock polymers, are known to seal defects in cell membranes. In previous experiments using laboratory animals, we have exploited this capability using polyethylene glycol (PEG) to repair spinal axons after severe, standardized spinal cord injury (SCI) in guinea pigs. Similar studies were conducted using a related co-polymer Poloxamer 188 (P 188). He...

This study aimed to optimize the preparation conditions of pachyman (PHY)-loaded poly(d,l-lactic acid) (PLA) (PHYP) nanospheres by response surface methodology, explore their characteristics, and assess their effects on splenic lymphocytes. Double emulsion solvent evaporation was used to synthesize PHYP nanospheres, and the optimal preparation conditions were identified as a concentration of po...

Enzalutamide (ENZ) is a BCS class II, fast crystallizing, hydrophobic compound that has solubility limited absorption in vivo. Ternary solid dispersion of was prepared with water-soluble polymers Soluplus (SOL) and Poloxamer P 188 (POL) by solvent evaporation spray drying technique. Initially, different ratios Soluplus: solvents were used to prepare dispersions evaluated for the dissolution enh...

Isradipine belong to dihydropyridine (DHP) class of calcium channel blockers (CCBs). It is used in the treatment hypertension, angina pectoris, addition Parkinson disease. goes under BCS II drug (low solubility-high permeability). The will experience extensive first-pass metabolism liver, therefore, oral bio-availability be approximately15 24 %.
 
 aim this study was formulate and opt...

The aim of this study was to produce niflumic acid nanoparticles without using an organic solvent, in order to achieve an increased rate of dissolution of the final products. Co-grinding with excipients was used to decrease the particle size. Poloxamer 188 (P) and mannitol (M) applied as co-grinding materials stabilized the system, preventing aggregation of the nanocrystals. The morphology and ...

Nanoparticles made of poly(butyl cyanoacrylate) (PBCA) or poly(lactic-co-glycolic acid) (PLGA) coated with polysorbate 80 or poloxamer 188 enable the transport of cytostatics such as doxorubicin across the blood-brain barrier (BBB). Following intravenous injection to rats bearing intracranially the very aggressive glioblastoma 101/8 these particles loaded with doxorubicin significantly increase...