-To obtain more insight in the ring-opening polymerization of lactones, complex formation of the initiators tetraphenyltin, stannous octoate, tin tetrachloride, aluminium bromide and triisobutylaluminium (TIBA), and the monomers L(-)-lactide, D,e-lactide and glycolide was studied by i.r.-spectroscopy. When equimolar benzene or toluene solutions of initiators and monomers were combined, only com...

Although it has been repeatedly indicated the importance to develop implantable devices and cell culture substrates with tissue-specific rigidity, current commercially available products, in particular substrates, have rigidity values well above most tissues body. Herein, six resorbable polyester films were fabricated using compression moulding a thermal presser into tailored stiffness by appro...

Biodegradable micelle systems with both extracellular stabilities and specific targeting properties are highly desirable for anti-cancer drug delivery. Here, we report a biodegradable and crosslinkable poly(propylene fumarate)-co-poly(lactide-co-glycolide)-co-poly(ethylene glycol) (PPF-PLGA-PEG) copolymer conjugated with folate (FA) molecules for receptor-mediated delivery of doxorubicin. Micel...

Bone scaffolds are often fabricated by initially producing custom-made filaments twin-screw extruder and subsequently fabricating into 3D using fused deposition modelling. This study aims to directly compare the effect of two alternative silica-rich filler materials on thermo-mechanical properties such after extrusion printing. Poly (DL-lactide-co-glycolide) (PDLGA) was blended with either 45S5...