Melt electrowriting (MEW) is an additive manufacturing technology enabling the production of highly porous microfiber scaffolds, suggested in particular for use biomedical applications, including drug delivery. Indomethacin (IND) a nonselective anti-inflammatory drug, which sublingual delivery could offer advantages such as rapid absorption by veins mouth floor while overcoming side effects per...

Poly(lactic-co-glycolic acid) (PLGA) is a biocompatible member of the aliphatic polyester family of biodegradable polymers. PLGA has long been a popular choice for drug delivery applications, particularly since it is already FDA-approved for use in humans in the form of resorbable sutures. Hydrophobic and hydrophilic drugs are encapsulated in PLGA particles via single- or double-emulsion. Brief...

The host response against foreign materials designates the biocompatibility of intravenously administered microcapsules and thus, widely affects their potential for subsequent clinical use as artificial oxygen/drug carriers. Therefore, body distribution and systemic parameters, as well as markers of inflammation and indicators of organ damage were carefully evaluated after administration of sho...

In developing a drug delivery strategy, issues of absorption, distribution, metabolism, and elimination must be considered. The eye presents unique opportunities and challenges when it comes to the delivery of pharmaceuticals. While absorption by this route is bungling, there are few side effects with conventional ocular dosage forms. Hence, ocular inserts were prepared with prolonged release o...

A sugar poly(orthoester)-based drug delivery system was constructed to achieve acidity-enhanced drug delivery and cell killing.

Objective(s): Irinotecan is a potent anti-cancer drug from camptothecin group which inhibits topoisomerase I. Recently, biodegradable and biocompatible polymers such as poly lactide-co-glycolides (PLGA) have been considered for the preparation of nanoparticles (NPs). Materials and Methods: In this study, irinotecan loaded PLGA NPs were fabricated by an emulsification/solvent diffusion method to...

The optical absorption and fluorescence of silver nanoclusters (AgNCs) are widely exploited in many different application fields such as sensors, bio-imaging, drug delivery, etc. In the sensor field, devices highly versatile thanks to their ease fabrication low costs and, therefore, optimal candidates replace expensive apparatuses commonly used. this study, we synthesized AgNCs aqueous phase by...

Abstract Objective We aimed to systematically review and synthesise evidence on the clustering of a broad range health-related behaviours amongst 11–16 year olds. Method A literature search was conducted in September 2019. Studies were included if they used cluster analysis, latent class prevalence odds ratios, principal component analysis or factor considered at least three interest among olds...