The design of molecules that damage a selected DNA sequence provides a formidable opportunity for basic and applied biology. For example, such molecules offer new prospects for controlled manipulation of the genome. The conjugation of DNA-code reading molecules such as polyamides to reagents that induce DNA damages provides an approach to reach this goal. In this work, we showed that a bipyridi...

Synthesis ofBismaleimidei.e.bis (4-maleimidophenyl) Sulphone (B) and Michael adduct of B with 4,42 Di amino Diphenyl methane and blended with allylnadicimides i.e. bis (4allylnadicimidophenyl) methane (S) ,1,6-allylnadicimidohexane(V) , and N-allylnadic-imide(L) was carried out at 280 oC for 1hr. The cure behavior of the blend resins was measured by DSC.The thermal stability of cured resins was...

Perylene-imide derivatives are industrially important pigments that exhibit a variety of shades from red via maroon to black. In the present investigation, we have synthesized novel perylene-imide derivatives with pyridyl rings in an attempt to apply them for H2 gas sensors based upon proton acceptors. The two N atoms of the pyridyl rings which work as proton acceptors are found to remain unbon...

Aberrant overexpression of ERG induced by the TMPRSS2-ERG gene fusion is likely involved in the development of prostate cancer. Synthetic pyrrole-imidazole (PI) polyamides recognize and attach to the minor groove of DNA with high affinity and specificity. In the present study, we designed a PI polyamide targeting TMPRSS2-ERG translocation breakpoints and assessed its effect on human prostate ca...

Ultrafast recombination observed from several perylene imide sensitizers bound to NiO appears to align with Marcus normal region behaviour; this indicates recombination to intra-bandgap states.

Imide electrolyte salts have received increasing interest in lithium–sulfur battery (LSB) research due to their oxidation capacity, thermal stability, and cycling stability. Although the ionic conductivity of imide electrolytes is moderate, a LSB with exhibits improved charge–discharge (CD) capacity Coulombic efficiency. Here, we applied an effective strategy suppress polysulfide dissolution by...

In this study, acicular nano-hydroxyapatite (n-HA) was used to make a new biomimetic composite with polyamide (poly hexamethylene adipamide) by a unique technique. The physical and chemical characteristics of the composites were tested. It was found that these synthesized n-HA crystals were similar to bone apatite in size, phase composition and crystal structure. The biomimetic n-HA crystals we...

The Nucleosome Core Particle (NCP) is the minimal unit in eukaryotic chromatin and a unique target for DNA-binding polyamides. The ability to modulate the stability of nucleosomes would be a useful tool for molecular biology and gene regulation. A series of polyamide clamps designed to differentiate between the NCP and B-form DNA were synthesized and analyzed using DNase I footprinting. In addi...

In the title mol-ecule, C16H14ClNO4, the four essentially planar atoms of the imide group [r.m.s. deviation = 0.0286 (11) Å] form a dihedral angle of 77.36 (13)° with the naphtho-quinone group [maximun deviation = 0.111 (2) Å for the carbonyl O atom in the naphthalene 1-position] and the two imide carbonyl groups are oriented anti with respect to each other. In the crystal, mol-ecules are conne...

20 new poly(ester-imide)s and poly(imide-urethane)s structures were synthesized using low temperature solution condensation polymerization. These compounds were optically active, capable of emitting circularly polarized light. The results indicated that the efficiency of the compounds much higher under this synthesis method. Cost effectiveness and short process were other advantages of this syn...