The transformation response of peripheral blood lymphocytes in vitro to human arterial and muscle antigen has been studied in patients with polymyalgia rheumatica, polymyositis, rheumatoid arthritis, and polyarteritis, and polyarteritis nodosa and in unrelated controls. Lymphocytes from patients with polymyalgia rheumatica showed transformation responses significantly higher to artery antigen t...

1. Periarteritis nodosa is a specific infectious disease which is transmissible to the rabbit. 2. The lesions induced in rabbits are identical with those occurring in man and consist of exudative and degenerative processes within the walls of the smaller arteries resulting in aneurysmal formations and thromboses. 3. The microorganism inducing the disease is capable of going through a Berkefeld ...

early diagnosis (often based on the detection of angiokeratomas) is important, as timely treatment can prevent the development of serious, irreversible complications. Dermatologists can play a key role in this respect. Enzyme replacement therapy (with agalsidase alpha) is the only specific treatment available for Fabry disease, and has been shown to stabilize renal function and reduce left vent...

A case is presented of a 16-year-old boy with angiographically proven polyarteritis nodosa who developed a multiple sclerosis like syndrome affecting the brain stem and cerebrum. His serum demyelinated nerve in tissue culture. The case is reviewed in detail and the mechanism of myelotoxicity is discussed.

An acute confusional state, which developed in a patient with polyarteritis nodosa (PAN), proved to be secondary to inappropriate secretion of antidiuretic hormone and consequent hyponatraemia. This is a very unusual complication of PAN and may well reflect a direct stimulation of the supraoptic nuclei owing to cerebral vasculitis.

The pathogenesis of the vascular lesions of polyarteritis nodosa found in young rats with experimental renal hypertension is described. The panarteritic lesion was a product of the combination of renal injury and feeding sodium chloride. It began with a fibrinoid necrosis of the intima and media which was followed by an extensive inflammatory reaction with subsequent fibrosis of all layers of t...

aneurysms (Figure 1a). There were no signs nor sympIntroduction toms of polyarteritis nodosa nor microscopic polyarteritis. The arterio-venous fistula was successfully treated Renal aneurysms are common in polyarteritis nodosa, by embolization. The patient received antibiotics for either idiopathic or associated with HBV or HCV 10 weeks (teicoplanin, ofloxacin and meticillin). Due infection [1]...

Two patients with liver disease due to polyarteritis nodosa are described. They presented in a similar manner, with a swinging fever, a polymorphonuclear leucocytosis and high alkaline phosphatase levels, but the natural history of the illness was different, with revocery in one and death in the other.

The clinical, histological, and immunohistochemical features of two cases of apparently isolated arteritis of the epididymis are presented. The aetiology and pathogenesis of the condition are discussed. Immunoglobulin and complement were shown in the acute arterial lesions, but this is not conclusive evidence that isolated arteritis is either an immune complex disease or a forme fruste of polya...

Allergic granulomatosis and angiitis is a disorder characterized by extravascular granulomas, hypereosinophilia, and pulmonary and systemic small-vessel vasculitis. The combination of allergic granulomatosis and angiitis is associated with asthma, typically of adult onset, and allergic rhinitis.1 Churg and Strauss first described this disorder in 1951, when they reviewed 13 autopsy cases that w...