The weight of a device is an ergonomic criterion as well. Devices that are carried and operated by people may not exceed a weight of 5 kg (11 lbs.). Previously, this was achieved by using lowdensity materials, such as aluminum or polyamide. An additional weight reduction, however, can be obtained through the use of ABS plastics and the FDM process. The density differences of ABS and polyamide d...

When targeted to sequences adjacent to a TATA element, pyrrole-imidazole (Py-Im) polyamides inhibit the DNA binding activity of TATA box binding protein (TBP) and basal transcription by RNA polymerase II. In the present study, we scanned the human immunodeficiency virus type 1 promoter for polyamide inhibition of TBP binding and transcription using a series of DNA constructs in which a polyamid...

According to UNEP and FAO reports, the fishing nets abandoned in seas around world represent approximately 10% of plastic waste present oceans. These nets, also called ghost can be degraded over time, releasing microplastics contaminating environment. Studying presence amount an area impacted by Gulf Cefalù, northern coast Sicily, Italy help understand level contamination these zones. The plann...

The biodistribution profiles in mice of two pyrrole-imidazole polyamides were determined by PET. Pyrrole-imidazole polyamides are a class of small molecules that can be programmed to bind a broad repertoire of DNA sequences, disrupt transcription factor-DNA interfaces, and modulate gene expression pathways in cell culture experiments. The (18)F-radiolabeled polyamides were prepared by oxime lig...

Ultrafine phase change nanofibers based on polyethylene glycol 1000 (PEG1000) as material (PCM) and polyamide 6 (PA6) a supporting were prepared in systematic manner planned by the Design-Expert® software using uniaxial electros-pinning. Research surface methodology (RSM) was carried out to optimize parameters conditions leading minimize fiber diameter. The effect of PEG content, applied voltag...

The potential use of shade covers to reduce evaporation from agricultural reservoirs motivated this study on the effect of black polyethylene shade on the evaporation rate from a small water body (Class-A pan) and of its driving variables. Evaporation was measured hourly in two pans during the summer in Cartagena (Spain), along with the measurements of air temperature and humidity, water temper...

BACKGROUND After the umbilical cord is cut, premature neonates face numerous problems including hypothermia. With regard to serious complications of hypothermia and incapability of conventional methods in preservation of neonates' temperature after admission, the researcher decided to conduct a study on the effects of two polyethylene covers in prevention of hypothermia among premature neonates...

We recently developed a new type of pyrrole (Py)-imidazole (Im) polyamide-tetrahydrocyclopropabenzindolone (CBI) conjugate with an indole linker as a stable sequence-specific alkylating agent. In this study, we investigated the gene silencing activities of polyamides A, B and C, which selectively alkylate specific sequences in the promoter region, non-coding strand and coding strand, respective...

This research investigated the direct bonding mechanism of dissimilar materials such as metals and plastic by the conventional hot pressing process. The press area of 4 x 4 mm2 was used for direct bonding. The results of the study showed that titanium was completely bonded to polyamide 66. On the other hand, titanium was not bonded to polystyrene. In the case of bonding material of titanium wit...

Vascular endothelial growth factor (VEGF) and its receptors have been implicated as key factors in tumor angiogenesis that are up-regulated by hypoxia. We evaluated the effects of DNA-binding small molecules on hypoxia-inducible transcription of VEGF. A synthetic pyrrole-imidazole polyamide designed to bind the hypoxia response element (HRE) was found to disrupt hypoxia-inducible factor (HIF) b...