Over the past years, emergence of various therapeutic approaches has attracted so much consideration, but chemotherapy remains most effective way in experimental practice. However, due to obstacles and difficulties, there is a limitation for additional clinical presentation outdated chemical treatments such as paclitaxel doxorubicin. Some barriers are severe side effects, profound cytotoxicity,...

Reduction-triggered breakable polymeric micelles incorporated with MTX were prepared using amphiphilic PAA-g-PEG copolymers having S-S bonds in the backbone. The micelles were spherical with diameters less than 70 nm. The micelles could encapsulate the hydrophobic MTX in the hydrophobic core. The drug loading content and drug loading efficiency of the micelles were highly dependent on the copol...

Nanoassemblies from amphiphilic block copolymers are promising nanomedicine platforms for cancer diagnosis and therapy due to their relatively small size, high loading capacity of drugs, controlled drug release, in vivo stability and prolonged blood circulation. Recent clinical trials with self-assembled polymeric micelles incorporating anticancer drugs have shown improved antitumor activity an...

Amphiphilic surfactants, molecules with chemical moieties that interact differently with the solvating medium, are important for technological applications and ubiquitous in biology. Understanding how to control surfactant properties is, therefore, of wide-ranging importance. Using a combination of light scattering experiments and field theory, we demonstrate that the behavior of polymeric surf...

Nanotechnology, shortened to nanotech, is the study of the controlling of matter on an atomic and molecular scale. Generally, nanotechnology deals with structures sized between 1 to 100 nanometer in at least one dimension and involves developing materials or devices within that size. The use of nanotechnology in the field of pharmaceutics and drug delivery has grown over the last few years, so ...

The combination of chemotherapy drugs attracts more attention in clinical cancer trials. However, the poor water solubility of chemotherapeutic drugs restricts their anticancer application. In order to improve antitumor efficiency and reduce side effects of free drugs, we prepared paclitaxel (PTX) and honokiol (HK) combination methoxy poly(ethylene glycol)-poly(caprolactone) micelles (P-H/M) by...

BACKGROUND Nowadays, many cytotoxic anticancer drugs exhibit low solubility and poor tumor selectivity, which means that the drug formulation is very important. For example, in the case of paclitaxel (PTX), Cremophor EL(®) (BASF, Ludwigshafen, Germany) needs to be used as a solubilizer in its clinical formulation (Taxol(®), Bristol-Myers Squibb, New York, NY), although it can cause serious side...

The recent development of light irradiation systems has facilitated the emergence of new therapies based on light-sensitive drugs. However, photosensitizers have a tendency to self-associate in physiologic environment, leading to a loss of their physical properties. Hence, nanometric formulations have been assessed, because this limits self-association and enables accumulation in solid tumors o...