We report a rare case of disseminated coccidioidomycosis with multifocal musculoskeletal involvement. The patient presented to the emergency department with left shoulder pain and swelling. Magnetic resonance imaging of the left shoulder revealed enhancing soft tissue masses, bony lesions, and fluid collections in and around the glenohumeral joint with involvement of the proximal humerus, gleno...

Fournier’s gangrene (FG) is a rapid progressive disease with high mortality and is caused by polymicrobial infection. FG usually begins with infection and affects fascias in (the perianal and) perineal regions as well as the abdominal wall and other organs. Although this disease has been recognized for many years, there are only a few cases reported in the world and few from China. Here, we rep...

Sepsis is a severe syndrome that arises when the host response to an insult is exacerbated, leading to organ failure and frequently to death. How a chronic infection that causes a prolonged Th1 expansion affects the course of sepsis is unknown. In this study, we showed that mice chronically infected with Toxoplasma gondii were more susceptible to sepsis induced by cecal ligation and puncture (C...

Abstract Background Burkholderia cepacia , an opportunistic pathogen mainly affecting patients with cystic fibrosis or immunocompromised, has rarely been documented as a cause of corneal infection. The clinical and microbiological profiles B. keratitis are reported herein. Methods We retrospectively reviewed the medical record 17 culture-proven keratitis, treated between 2000 2019 at Chang Gung...

Polymicrobial infections constitute small ecosystems that accommodate several bacterial species. Commonly, these bacteria are investigated in isolation. However, it is unknown to what extent the isolates interact and whether their interactions alter bacterial growth and ecosystem resilience in the presence and absence of antibiotics. We quantified the complete ecological interaction network for...

Understanding the pathology resulting from Staphylococcus aureus and Pseudomonas aeruginosa polymicrobial wound infections is of great importance due to their ubiquitous nature, increasing prevalence, growing resistance to antimicrobial agents, and ability to delay healing. Methicillin-resistant S. aureus USA300 is the leading cause of community-associated bacterial infections resulting in incr...

Polymicrobial sepsis induces organ failure and is accompanied by overwhelming inflammatory response and impairment of microbial killing. Peroxisome proliferator-activated receptor (PPAR)-γ is a nuclear receptor with pleiotropic effects on lipid metabolism, inflammation, and cell proliferation. The insulin-sensitizing drugs thiazolidinediones (TZDs) are specific PPAR-γ agonists. TZDs exert anti-...

background: neutropenic patients are vulnerable to a wide spectrum of infectious agents. the aim of this study was to determine the current frequency of bacterial infections in patients with nosocomial fever and neutropenia. methods: in a retrospective study, the neutropenic patients’ specimens with nosocomial fever were cultured on blood and macconkey agar plates and evaluated at microbiology ...

CONTEXT Severe acute pancreatitis is associated with high mortality with infectious complications being the most common cause of mortality. OBJECTIVE To analyze the prevalence and characteristics of pancreatic and extrapancreatic infection in patients with severe acute pancreatitis. DESIGN Prospective study over a one-year period. PATIENTS Fifty-one consecutive patients with severe acute ...

We report a case of postsurgical wound infection of polymicrobial etiology caused by Serratia marcescens and Pseudomonas aeruginosa following the use of a radial forearm free flap for oncological tongue reconstruction. S. marcescens was a producer of SHV-12 extended-spectrum beta-lactamase (ESBL). This is the first report from India of this ESBL. S. marcescens and P. aeruginosa were resistant t...