Topical drug dosage forms such as ointments and creams can be easily removed through wetting, movement and contact. The new bioadhesive formulations with enhanced local anesthetic effects are needed for topical administration. The adhesive capacity of hydroxypropyl methylcellulose (HPMC) was determined by measuring the maximum detachment force and the adhesion work with an auto peeling test...

Aqueous emulsion acrylic adhesive was prepared by batch polymerization With 2-ethylhexyl acrylate (2-EHA) and butyl (BA) as soft monomers, methyl methacrylate (MMA) hard monomer, acid (AA), amide (AM) hydroxyethyl (HEA) hydrophilic functional dodecanethiol (NDM) molecular weight regulator, Sodium dodecyl benzene sulfonate (SDBS) octyl phenol polyoxyethylene ether (op-10) mixed emulsifiers, ammo...

STUDY OBJECTIVES We have shown in previous studies that epinephrine administered intranasally is a feasible route of administration during cardiopulmonary resuscitation (CPR). To promote the absorption of epinephrine we administered phentolamine prior to epinephrine and used a bile salt as a vehicle to dissolve the epinephrine. The purpose of this study was to compare the effect of two differen...