نتایج جستجو برای: polyphenols

تعداد نتایج: 10827  

2013
ANUBHUTI SHARMA

Antioxidant activity and polyphenols were determined by Microwave assisted extraction technique (MAE) from nonedible parts of Indian tropical fruits. Antioxidant activity was performed using FRAP, ABTS and DPPH assays. Nine polyphenols were quantified by LC-MS/MS. Results showed that skin extract of A. comosus contained highest value for all antioxidant assays. Polyphenolic compounds were found...

2016
Gangcheng Wu Stuart K. Johnson Janet F. Bornman Sarita J. Bennett Michael W. Clarke Vijaya Singh Zhongxiang Fang

Polyphenols in sorghum grains are a source of dietary antioxidants. Polyphenols in six diverse sorghum genotypes grown under two day/night temperature regimes of optimal temperature (OT, 32/21 °C and high temperature (HT, 38/21 °C) were investigated. A total of 23 phenolic compounds were positively or tentatively identified by HPLC-DAD-ESIMS. Compared with other pigmented types, the phenolic pr...

Journal: :Antioxidants & redox signaling 2005
Amit K Garg Thomas A Buchholz Bharat B Aggarwal

The treatment of cancer with chemotherapeutic agents and radiation has two major problems: time-dependent development of tumor resistance to therapy (chemoresistance and radioresistance) and nonspecific toxicity toward normal cells. Many plant-derived polyphenols have been studied intently for their potential chemopreventive properties and are pharmacologically safe. These compounds include gen...

Journal: :Journal of inorganic biochemistry 2011
Nathan R Perron Carla R García Julio R Pinzón Manuel N Chaur Julia L Brumaghim

Inhibition of copper-mediated DNA damage has been determined for several polyphenol compounds. The 50% inhibition concentration values (IC(50)) for most of the tested polyphenols are between 8 and 480 μM for copper-mediated DNA damage prevention. Although most tested polyphenols were antioxidants under these conditions, they generally inhibited Cu(I)-mediated DNA damage less effectively than Fe...

2013
Nathalie Mignet Johanne Seguin Guy G. Chabot

Dietary polyphenols, including flavonoids, have long been recognized as a source of important molecules involved in the prevention of several diseases, including cancer. However, because of their poor bioavailability, polyphenols remain difficult to be employed clinically. Over the past few years, a renewed interest has been devoted to the use of liposomes as carriers aimed at increasing the bi...

2016
Rui Li Xiang Gui Chen Kun Jia Zhen Ping Liu Hai Yan Peng

Plant polyphenols derived from pomegranates are natural health-promoting components, and their bioactivities are well proved. However, the systematic studies of polyphenols constituents and cytotoxic ability in fruit parts of pomegranates derived from different Chinese cultivars have not been studied yet. In this report, a validated and sensitive HPLC-DAD method and fluorescence spectrophotomet...

Journal: :Journal of investigational allergology & clinical immunology 2006
T Enomoto Y Nagasako-Akazome T Kanda M Ikeda Y Dake

BACKGROUND We often encounter persistent allergic rhinitis due to house dust mites in the practice of otolaryngology, and its prevalence in Japan is high (18.7%). Persistent allergic rhinitis is usually treated with antihistamines and local steroids, but they often cause adverse effects such as sedation and drowsiness. Polyphenols derived from apples have been reported to suppress histamine rel...

2013
Sheeja Aravindan Caroline R. Delma Somasundaram S. Thirugnanasambandan Terence S. Herman Natarajan Aravindan

Pancreatic cancer (PC) remains the fourth leading cause of cancer death with an unacceptable survival that has remained relatively unchanged over the past 25 years. The presence of occult or clinical metastases at the time of diagnosis together with the lack of effective chemotherapies pose a dire need for designing new and targeted therapeutic deliverables that favors the clinical outcome. Her...

Journal: :The Journal of pharmacology and experimental therapeutics 2009
Kathryn A Seely Mark S Levi Paul L Prather

The dietary polyphenols trans-resveratrol [5-[(1E)-2-(4-hydroxyphenyl)ethenyl]-1,3-benzenediol; found in red wine] and curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1E,6E-heptadiene-3,5-dione] (found in curry powders) exert anti-inflammatory and antioxidant effects via poorly defined mechanisms. It is interesting that cannabinoids, derived from the marijuana plant (Cannabis sativa), produce simi...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2006
Xia Wen Thomas Walle

To better understand the relationship between the chemical structure and biological fate of dietary polyphenols, the hepatic metabolic stability and intestinal absorption of methylated polyphenols, in comparison with unmethylated polyphenols, were investigated in pooled human liver S9 fraction and human colon adenocarcinoma (Caco-2) cells. Consistent with previous in vivo studies, the two well ...

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