نتایج جستجو برای: polysaccharide vaccine
تعداد نتایج: 127703 فیلتر نتایج به سال:
As a defective anti-polysaccharide response can exist in the absence of an immunoglobulin deficiency, a series of 26 patients with bronchiectasis of unknown aetiology was vaccinated with a 23-valent pneumococcal polysaccharide vaccine. All patients suffered from recurrent respiratory tract infections. When measuring total antibody levels to pneumococcal serotypes 3, 4 and 9, a normal polysaccha...
BACKGROUND Pneumococcal polysaccharide conjugate vaccines prevent pneumococcal disease in infants, but their efficacy against pneumococcal community-acquired pneumonia in adults 65 years of age or older is unknown. METHODS In a randomized, double-blind, placebo-controlled trial involving 84,496 adults 65 years of age or older, we evaluated the efficacy of 13-valent polysaccharide conjugate va...
Pneumococcal polysaccharide vaccine has been licensed for use in the United States for >30 years, and two-thirds of the elderly population in the United States have received this vaccine. Observational studies have demonstrated that pneumococcal polysaccharide vaccine reduces the risk of invasive pneumococcal disease in immunocompetent elderly individuals, but neither observational studies nor ...
OBJECTIVES The aim of the study was to understand more about pre-travel preparations and itineraries of business and occupational travelers. METHODS De-identified data from 18 Global TravEpiNet clinics from January 2009 to December 2012 were analyzed. RESULTS Of 23,534 travelers, 61% were non-occupational and 39% occupational. Business travelers were more likely to be men, had short times t...
CONTEXT Revaccination of healthy adults with pneumococcal polysaccharide vaccine (PPV) within several years of first vaccination has been associated with a higher than expected frequency and severity of local injection site reactions. The risk of adverse events associated with revaccination of elderly and chronically ill persons 5 or more years after first vaccination, as is currently recommend...
OBJECTIVES: To describe the characteristics of pneumococcal isolates obtained from patients with invasive pneumococcal disease in The Gambia. METHODS: Pneumococcal isolates were obtained from children aged < or =6 years with invasive pneumococcal disease during a Haemophilus influenzae vaccine effectiveness study (1997-2002) and from patients with invasive pneumococcal disease admitted to the M...
The synthesis of Vi polysaccharide, a major virulence determinant in Salmonella enterica serotype Typhi (S. Typhi), is under the control of two regulatory systems, ompR-envZ and rscB-rscC, which respond to changes in osmolarity. Some S. Typhi isolates exhibit over-expression of Vi polysaccharide, which masks clinical detection of LPS O-antigen. This variation in Vi polysaccharide and O-antigen ...
1 0.17 (0.13-0.22) 2.04 (1.49-2.80) <.0001 2 0.28 (0.23-0.35) 12.48 (9.66-16.12) <.0001 3 0.37 (0.26-0.53) 13.74 (10.55-17.91) <.0001 4 0.08 (0.06-0.10) 2.37 (1.76-3.20) <.0001 5 0.26 (0.20-0.34) 2.77 (2.15-3.57) <.0001 6B 0.14 (0.12-0.17) 0.31 (0.23-0.42) <.05 7F 0.10 (0.08-0.14) 2.58 (1.98-3.37) <.0001 8 0.26 (0.20-0.32) 13.59 (10.72-17.23) <.0001 9N 0.12 (0.09-0.15) 3.06 (2.18-4.30) <.0001 9...
CONTEXT A conjugate vaccine targeting 7 pneumococcal serotypes was licensed for young children in 2000. In contrast to the 23-valent polysaccharide vaccine used in adults, the 7-valent conjugate vaccine affects pneumococcal carriage and transmission. Early after its introduction, incidence of invasive pneumococcal disease declined among older adults, a group at high risk for pneumococcal diseas...
4. Polysaccharide vaccine (PPV23), used in subjects older than 2 years since decades ago, includes a greater number of serotypes (23), but it does not generate immune memory, antibody levels decrease with time, causes an immune tolerance phenomenon, have no effect on nasopharyngeal colonization and has not shown vaccine effectiveness in these risk groups in the United Kingdom despite a 75% of v...
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