Diabetes insipidus (DI) is a form of polyuria-polydipsia syndrome characterised by excretion large amounts hypotonic urine and excessive drinking.1,2 Given the challenges in investigation syndrome,3 web-based clinical decision support tool ‘The PP App’ (https://pathologyapps.shinyapps.io/PolyuriaPolydipsia/) has been created with up-to-date evidence-based information. In this Shiny app, initial...

OBJECTIVES To describe the demographic characteristics and clinical presentation of Omani children with type 1 diabetes mellitus at Sultan Qaboos University Hospital, Muscat, Oman. METHODS A retrospective analysis of all children with type 1 diabetes mellitus attending the Pediatric Endocrine Unit at Sultan Qaboos University Hospital, Oman from June 2006 to May 2013. RESULTS One hundred and...

Because anecdotal reports suggest that concentrations of atrial natriuretic peptide are raised during tachycardias, plasma immunoreactive atrial natriuretic peptide concentrations were measured in 34 consecutive patients when tachycardia was diagnosed and again five and 15 minutes after conversion to sinus rhythm. Plasma atrial natriuretic peptide concentrations were raised in all but four pati...

Nocturia is one of the most bothersome of all urologic symptoms, yet even a rudimentary classification does not exist. We herein propose a classification system of nocturia based on a retrospective study. The records of 200 consecutive patients with nocturia were reviewed. Evaluation included history, micturition diary (including day, night, and 24-hr voided volume), postvoid residual urine (PV...

A five-year-old boy was referred to our pediatric clinic for evaluation of failure to thrive, headache, intermittent high fever, restlessness, polyuria, and polydipsia. His weight and height measurements were under the 3rd percentile. Clinical findings consisted of frontal bossing, carious teeth, O-bain deformity of the lower extremities, and moderate dehydration. The presence of metabolic alka...

The water intake in hypertensive rats was investigated. Rats made hypertensive by renal ischemia increased their water consumption by 75 per cent over the preoperative level. Polyuria was associated with this polydipsia and the independence of these occurrences from a number of other factors was demonstrated. It was found that the presence of a normal kidney exerted a compensatory influence whi...

Introduction Diagnosis of adrenal crisis and panhypopituitarism in patients with septic shock is difficult but crucial for outcome. Case A 66-year-old woman with metastasized breast cancer presented to the ED with respiratory insufficiency and septic shock after a 2-day history of the flu. After transfer to the ICU, corticosteroids were started in addition to antibiotics, as the patient was v...