Covalent cavitand Zn(II)-porphyrins 17-20 were prepared via multistep syntheses. These host molecules show moderate to excellent binding affinities to N-methylimidazole and pyridine guests. The complexing behavior strongly depends on the spacer's length, number, and rigidity, in addition to the guest size. Cavitand capping and strapping of porphyrins strongly influence the complex formation and...

A series of parasubstituted tetraphenylporphyrin zirconium(IV) salicylate complexes (SA/5-SSAZr(IV)RTPP, R = p-H, p-CH3, p-NO2, p-Cl, SA = salicylate, and 5-SSA = 5-sulfosalicylate) have been synthesized, and the spectral properties of free base porphyrins, their corresponding metallated, and axially ligated zirconium(IV) porphyrin compounds were compared with each other. A detailed analysis of...

The delivery of oligonucleotides to appropriate intracellular compartments is crucial to their development as tools in gene function studies and as therapeutics. Here, we report the characterization of meso-substituted cationic porphyrins as a large class of water-soluble reagents for oligonucleotide delivery. These porphyrins form non-covalent complexes with single-stranded oligonucleotides an...

The suggestion of Duesberg (1) that prolonged ingestion of allylisopropylacetylcarbamide (Sedormid)’ may have induced acute porphyria in a human led later workers to produce this disorder in rabbits (2) and rats (3) by oral administration of the drug. Although this experimental procedure has facilitated the study of acute porphyria, the possibility remains that some of the porphyrin excreted in...

Supramolecular assemblies of a quantum dot (QD) associated to palladium(II) porphyrins have been developed to detect oxygen (pO2) in organic solvents. Palladium porphyrins are sensitive in the 0-160 Torr range, making them ideal phosphors for in vivo biological oxygen quantification. Porphyrins with meso pyridyl substituents bind to the surface of the QD to produce self-assembled nanosensors. A...

PATIENT Male, 47 FINAL DIAGNOSIS: Porphyria cutanea tarda Symptoms: Chills • cough dry • thumb swelling MEDICATION - Clinical Procedure: - Specialty: Metabolic Disorders and Diabetics. OBJECTIVE Challenging differential diagnosis. BACKGROUND Porphyria cutanea tarda (PCT) is the most common type of the porphyria. It occurs due to the deficiency of enzyme uroporphyrinogen decarboxylase (URO...

The recently emerging class of MOFs based on porphyrins and phthalocyanines bearing alternative coordinating groups offers opportunities for functional materials.

Porphyrins are derivatives formed in the heme synthesis pathway and porphyrins afford a measure of xenobiotic exposure. The steps in the heme pathway most vulnerable to heavy metal inhibition are uroporphyrin decarboxylase (UROD) and coproporphyrinogen oxidase (CPOX) reactions. Mercury toxicity was associated with elevations in urinary coproporphyrin (cP), pentacarboxyporphyrin (5cxP), and prec...

LTHOUGH the primary precursors, the intermediates and most of the enzymes involved ir the biosynthetic chain of porphyrins are now known,’,2’3 knowledge of the tissue sites( s) of porphyrin formation is incomplete. Several earlier studies4’5 demonstrated that avian nucleated erythrocytes as well as rabbit bone marrow are active in this respect. Both tissues utilize either glycine and acetate ( ...

Information on changes in the urinary excretion pattern of porphyrins can be especially useful in the diagnosis of disorders of porphyrin metabolism. Most clinical laboratory procedures are designed for assay of uroporphyrin and coproporphyrin only, and in many cases even these are not cleanly separated. Hence, we developed a "high-performance" liquid-chromatographic procedure to separate and q...