More than two-thirds of breast cancers occur in post-menopausal women, and depend on the estrogens for their proliferation and survival. For the treatment of estrogen-dependent breast cancers, two major treatment options are now available. One is selective estrogen receptor modulator (SERM) such as Tamoxifen and another is aromatase inhibitor such as Anastrozole, Letrozole and Exemestane, which...

STUDY QUESTION Does sex-steroid feedback influence gonadotrophin responses to kisspeptin-10? SUMMARY ANSWER Gonadotrophin response to kisspeptin-10 is enhanced in sex-steroid deficient post-menopausal women and suppressed in women taking pharmacological doses of exogenous estrogen and progestogen. WHAT IS KNOWN ALREADY Kisspeptin, a novel hypothalamic neuropeptide, stimulates gonadotrophin ...

Background: This study aims to understand the relationship between menopausal status and the presence of Metabolic Syndrome in women from 40 to 65 years, as well as to describe the distribution of each component of Metabolic Syndrome according to sample characteristics. Methods: A cross-sectional study was conducted with 551 women treated at a clinic in southern Brazil. MetS and its components ...

Background Some studies have already proposed an inverse association between vitamin D levels and breast density. As breast density is already considered an established risk factor for breast cancer, such a connection could offer a new starting point for the prevention of breast cancer. Material and Methods To investigate this suggested connection, a total of 412 pre- and 572 post-menopausal wo...

Introduction: This study was conducted to evaluate prevalence and risk factors for diagnostic discordance for osteoporosis due to different T-scores of lumbar spine and femoral neck. Methods: In this cross sectional study demographic, anthropometric and risk factors for osteoporosis were derived from a database on 3,039 post-menopausal women who underwent bone densitometry for the first time i...

Breast cancer development is intimately related to DNA damage and DNA repair failures. The aim of this study was to investigate the level of DNA damage in the lymphocytes of breast cancer patients and to find its association with age and menopausal status. This study comprises of 75 breast cancer patients, equally categorized into three groups, based on the disease stage namely, non metastatic ...

Data from both in vivo and in vitro experiments demonstrated that glabridin and glabrene are similar to estradiol-17beta in their stimulation of the specific activity of creatine kinase, although at higher concentrations, but differ in their extent of action and interaction with other drugs. In pre-menopausal human bone cells, the response to estradiol-17beta and glabridin (at higher concentrat...

BACKGROUND Quality of life in post-menopausal women and menopausal symptoms are closely related concepts. Influence health education policy in order to promote health and adopt a menopause lifestyle requires alternative strategies, including health training programs with community - based interventions. The current study aims to survey the effects of support groups on quality of life of post-me...

BACKGROUND Aging brings about a number of degenerative changes in the body. The aging process in-creases its pace after the menopause. Women notice functional limitations in their daily lives, including mobility problems, as early as in their forties. Gait is one of the most reliable parameters reflecting the body's overall function and condition. The aim of this study was to determine the effe...

PURPOSE/OBJECTIVES To describe sexuality, menopausal symptoms, and quality of life (QOL) in premenopausal women in the first year following hematopoietic cell transplantation (HCT)
. DESIGN One-year prospective longitudinal study. SETTING Stanford University Medical Center in California.
. SAMPLE 63 premenopausal female recipients of HCT with a mean age of 34.5 years. METHODS Three inst...