BACKGROUND Introduction of the heptavalent pneumococcal conjugate vaccine (PCV7) changed the epidemiology of invasive pneumococcal disease (IPD). We evaluated the changes that occurred after PCV7 introduction among Utah infants aged 1 to 90 days, too young to be fully immunized. METHODS We identified children <18 years with culture-confirmed IPD from 1997-2010. We analyzed demographic, clinic...

BACKGROUND Gram-negative bacillary (GNB) ventriculitis and meningitis are rare but serious complications after neurosurgery. Prospective studies on antibiotic treatment for these infections are lacking, and retrospective reports are sparse. At our hospital in Uppsala, Sweden, meropenem has been recommended as empirical therapy since 1996, with the addition of intraventricular gentamicin in case...

INTRODUCTION Complications of acute infective sinusitis are a therapeutic emergency. The purpose of this study was to determine the clinical presentation, microbiological pattern, treatment modalities and outcome of patients diagnosed to have acute rhinogenic orbital, intra- and extra-cranial complications from a developing country in Asia. METHODS A retrospective chart review from October 19...

BACKGROUND Sensorineural hearing loss is the most common sequela in survivors of bacterial meningitis (BM). In the past we developed a validated prediction model to identify children at risk for post-meningitis hearing loss. It is known that host genetic variations, besides clinical factors, contribute to severity and outcome of BM. In this study it was determined whether host genetic risk fact...

Background: Tuberculosis of the central nervous system is very common in South East Asia region and particularly in India. Despite of various diagnostic modalities and treatment options the outcome remains poor.Clinicians face many challenges in management of tubercular infections of the brain and spine. Material & Methods: Twenty five patients with CNS tuberculosis who had undergone neurosurge...