PURPOSE To evaluate the value of a new multi-stage surgical procedure using bilateral intracranial electroencephalogram (iEEG) prior and post complete corpus callosotomy (CC) for epileptogenic focus localization. METHOD Thirty patients with drug-resistant epilepsy underwent bilateral iEEG monitoring to localize epileptogenic focus for surgical treatment. Among them, bisynchronous epileptogeni...

In French, the prosody associated with post-focus sequences is usually described a steadily flat, the suppression of any tonal variation being explained by the semantic and pragmatic content of these sequences. This paper aims to show that postfocus sequences may be realized in different ways. An experimental analysis of various post-focus sequences has shown that three distinct prosodic realiz...

OBJECTIVE To compare postoperative seizure-free survival between older and younger adults. METHODS A retrospective cohort of 107 temporal lobe epilepsy patients with a diagnosis of mesial temporal sclerosis (MTS) received anterior temporal lobectomy (ATL) between 1993 and 2014. We divided the lower three quartiles (younger) and top quartile (older, all 47+ years) of patients, then reviewed pa...

We read with great interest the paper entitled ‘‘Immediate suppression of seizure clusters by corticosteroids in PCDH19 female epilepsy’’ by Higurashi et al. [1]. Clusters of febrile and afebrile seizures, mainly focal motor or hypomotor with affective symptoms, are typical of PCDH19 female epilepsy (PCDH19-FE) [2]. After first reporting on the excellent efficacy of corticosteroids in acute clu...

Mesial temporal lobe epilepsy is the most common, intractable seizure disorder in adults. It is associated with an asymmetric pattern of hippocampal neuron loss within the endfolium (hilus and CA3) and CA1, with limited pathology in extra-hippocampal regions. We previously developed a model of focally-evoked seizure-induced neuronal death using intra-amygdala kainic acid (KA) microinjection and...

BACKGROUND Describe an ictal EEG pattern of paradoxical lateralization in children with unilateral encephaloclastic hemispheric lesion acquired early in life. METHODS Of 68 children who underwent hemispherectomy during 2003-2005, scalp video-EEG and brain MRI of six children with an ictal scalp EEG pattern discordant to the clinical and imaging data were reanalyzed. Medical charts were review...