In this study, hydroxyapatite with the substitution of calcium cations by iron and phosphate silicate groups was synthesized via a mechanochemical method. The as-prepared compounds have general formula Ca10−xFex(PO4)6−x(SiO4)x(OH)2−xOx/2 x = 0–1.5. thermal stability studied ex situ annealing powders in furnace. It has been established that, at 800 °C for ≤ 0.5, partial decomposition substituted...

1. The mechanism of potassium transport across human distal colon was investigated in twenty-two individuals without evidence of bowel disease, by using a dialysis method in conjunction with measurements of the transepithelial potential difference (p.d.). 2. Whether potassium was absorbed or secreted depended on its initial concentration in the lumen. The potassium net flux was approximately ze...

Pathogenic infections and inflammation are very common ailments humans suffer. Upsurge of resistant pathogens has impeded the antimicrobial drug development process in recent years and the search of new antimicrobial agents is clearly evident from the literature. In line with these developments the synthesis of N-substituted aryl-2-({4-[(substituted aryl carbamoyl) methyl]-5-(pyridin-4-yl)-4H-1...

Unprecedented divergent rearrangements of cyclopropyl-substituted fluoroepoxides are reported. In the presence of a catalytic amount of benzoic acid, cyclopropyl-substituted fluoroepoxides efficiently undergo 1,5-fluorine migration. However, when the fluoroepoxides are heated with K2CO3 at 60 °C, 1,2-fluorine migration occurs. The 1,5-fluorine migration is believed to proceed via a carbocation ...

Preparation of several novel potassium salts of 4-substituted aminoazobenzenesulfonic acids by the simple and convenient reaction of insoluble 4-sulfobenzenediazonium chloride with some (hetero)cyclic amines of various ring sizes is reported. The compounds obtained have shown potential antiinflammatory activity in biological testing.

The problem of engineering a biomimetic mineralized layer on the surface native dental tissue (bio-template) was considered in our work. formation biotemplate is achieved with use nanocrystalline carbonate-substituted calcium hydroxyapatite (HAp), alkali, and complex polyfunctional organic polar amino acids. By applying set structural spectroscopic methods analysis we have confirmed HAp bio-tem...

ATP-sensitive potassium (KATP) channel openers have a relaxation effect due to the lower cellular membrane potential and inhibit calcium influx. There has been considerable interest in exploring KATP channel openers in the treatment of various diseases such as cardiovascular, cerebrovascular, and urinary system disease and premature labor. The purpose of this study was to synthesize 3,3,6,6-tet...

The 1,4-addition of a monofluoromethyl nucleophile to a variety of alpha,beta-unsaturated compounds has been achieved under mild conditions using either phosphines or potassium carbonate at room temperature. alpha-Substituted fluoro(phenylsulfonyl)methane easily undergoes Michael addition to alpha,beta-unsaturated ketones, esters, nitriles, sulfones, as well as propynoates at room temperature t...