the aim of the present research was to study the effects of weak cation exchange resins, polacrilex with exchangeable h+ and polacrillin potassium and strong cation exchange resin sodium polystyrene sulfonate on water uptake behavior of ranitidine hydrochloride. drug resin complexes (drc) were prepared and evaluated for the percentage of moisture gain when placed in a humidity chamber at 40e2 °...

THE PRESENT STUDIES INDICATE THAT ACCUMULATION OF DIGOXIN BY INTACT HUMAN ERYTHROCYTES IS THE RESULT OF TWO PROCESSES: binding of digoxin to the erythrocyte membrane and uptake of digoxin across the membrane into the cell. In contrast, accumulation of ouabain by human erythrocytes is entirely attributable to binding of this glycoside to the plasma membrane. Digoxin binding to the erythrocyte me...

A potassiumor sodium-activated cotransport of leucine occurs in brush-border membrane vesicles prepared from the midgut of larvae of Philosamia cynthia (Drury). The potassium chemical gradient can drive a twofold accumulation of leucine, which is greatly increased under experimental conditions that presumably provide an electrical potential difference (AT/;). Kinetic parameters show that leucin...

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Analysis of ion channel mutants is a widely used approach for dissecting ion channel function and for characterizing the mechanisms of action of channel-directed modulators. Expression of functional potassium channels in potassium-uptake-deficient yeast together with genetic selection approaches offers an unbiased, high-throughput, activity-based readout that can rapidly identify large numbers ...