In this paper, we study a deterministic method for particle transport in biological tissues. The method is specifically developed for dose calculations in cancer therapy and for radiological imaging. Generalized Fokker-Planck (GFP) theory [Leakeas and Larsen, Nucl. Sci. Eng. 137 (2001), pp. 236-250] has been developed to improve the Fokker-Planck (FP) equation in cases where scattering is forwa...

BACKGROUND Schizophrenia is a highly heritable neurodevelopmental disorder. A genetic variant of microRNA-137 (miR-137) has yielded significant genome-wide association with schizophrenia, suggesting that this miRNA plays a key role in its etiology. Therefore, a molecular network of interacting miR-137 targets may provide insights into the biological processes underlying schizophrenia. METHODS...

Evolutionary and physiological considerations argue that study of hyperthermophilic archaea should reveal new molecular aspects of DNA stabilization and repair. So far, these unusual prokaryotes have yielded a number of genes and enzymatic activities consistent with known mechanisms of excision repair, photo-reversal, and trans-lesion synthesis. However, other DNA enzymes of hyperthermophilic a...

Curriculum Change in South Africa Since 1994 The development of a national curriculum is a major challenge for any nation, and when a whole country depends on it to transform society in one broad stroke, it imposes tremendous expectations on such a curriculum. South Africa’s democratic government has inherited a divided and unequal system of education and must recognise that apartheid is not th...

a fourth-generation ziegler-natta catalyst was prepared to synthesize polypropylene (pp), which was stabilized by in situ polymerization employing lignin as antioxidant. the antioxidant properties of lignin were compared with those of the commercial antioxidant irganox 1010. the presence of lignin in the reaction medium slightly decreased the catalytic activity of the reaction. the isotacticity...

Event-Driven Process Chains (EPC) is a business process modeling language developed in a joint effort between SAP and the Institute of Information Systems of Saarbrücken in the context of the Architecture of Integrated Information Systems (ARIS) framework (Keller, Scheer, & Nüttgens, 1992). One of the initial purposes of EPC was to configure workflows in ERP software such as SAP R/3. As the lan...

Rabies is one of the negligible infectious diseases of public health concern and is responsible for over 30, 000 deaths in Asia and Africa alone (Mani and Madhusudana, 2013). The disease is 100% preventable provided post-exposure prophylaxis (PEP) treatment consisting of vaccines and immunoglobulins is initiated timely. Despite this, it continues to pose a threat due to ignorance of people in m...

If a locale is presented by a “flat site”, it is shown how its frame can be presented by generators and relations as a dcpo. A necessary and sufficient condition is derived for compactness of the locale (and also for its openness). Although its derivation uses impredicative constructions, it is also shown predicatively using the inductive generation of formal topologies. A predicative proof of ...

In the present study, we evaluated the mechanisms of CDC42 in association with the microRNA-137 (miR-137)-induced inhibition of human hepatocellular carcinoma (HCC). The gene expression levels of miR-137 were evaluated in HCC cell lines. Direct association of miR-137 with its downstream target, cell division control protein 42 (CDC42), was evaluated by dual-luciferase assay, western blot analys...