The intermediate filament protein, nestin, marks progenitor cells of the CNS. Such CNS stem cells are selectively labeled by placing GFP under the control of the nestin regulatory sequences. During early anagen or growth phase of the hair follicle, nestin-expressing cells, marked by GFP fluorescence in nestin-GFP transgenic mice, appear in the permanent upper hair follicle immediately below the...

The processes that precisely control the selection of ovulatory follicles from a growing cohort are poorly understood. This reduction in follicle number occurs through several phases of selection, consequently we limit the use of the term 'selection' to the first major reduction of growing follicles, at the pre- to early antral stage. The final process of selection, achieving the appropriate ov...

Inconsistent with the view that hair follicle stem cells reside in the matrix area of the hair bulb, we found that label-retaining cells exist exclusively in the bulge area of the mouse hair follicle. The bulge consists of a subpopulation of outer root sheath cells located in the midportion of the follicle at the arrector pili muscle attachment site. Keratinocytes in the bulge area are relative...

Previous studies relating to the effect on whisker growth of removal of various components of the whisker follicle have shown that both after removal of the dermal papilla alone and after removal of as much as the lower third of the follicle, regeneration of new dermal papillae and then the generation of whiskers may occur (Oliver, 1966 a, b). Histological studies of this regenerative phenomeno...

Anti-müllerian hormone (AmH) or müllerian inhibiting substance (mIS), is a dimeric protein part of the transforming growth factor (TGF)-beta subfamily. It plays two important roles in follicle genesis. First, it delays entrance of primordial follicle into pool of follicles in growth and secondly, it decreases the sensitivity of ovarian follicle toward follicle-stimulating hormone (FSH). The ova...

Thyroid tissues in coho salmon (Oncorhynchus kisutch) goiters showed marked regional variation in structure and ultrastructure. For the most part the follicles were small, were composed of tall epithelial cells, and con tained little or no colloid material. The follicle epithelial cells were essentially similar in fine structure to hyperac tive thyroids in mammals and one type of follicle in co...

Thyroid tissues in coho salmon (Oncorhynchus kisutch) goiters showed marked regional variation in structure and ultrastructure. For the most part the follicles were small, were composed of tall epithelial cells, and contained little or no colloid material. The follicle epithelial cells were essentially similar in fine structure to hyperactive thyroids in mammals and one type of follicle in cong...

The regulation of the periodic regeneration of hair follicles is complicated. Although Wnt10b has been reported to induce hair follicle regeneration, the characteristics of induced hair follicles, especially the target cells of Wnt10b, have not yet been clearly elucidated. Thus, we systematically evaluated the expression and proliferation patterns of Wnt10b-induced hair follicles. We found that...

Fertility in mammals is dependant on females having an adequate primordial follicle pool to supply oocytes for fertilization. The formation of primordial follicles is called ovarian follicular assembly. In rats and mice progesterone and estradiol have been shown to inhibit follicle assembly with assembly occurring after birth when the pups are removed from the high-steroid maternal environment....

INTRODUCTION Stem cells from hair follicle have great therapeutic applications in regenerative medicine as sources of cells for transplantation. The differentiation pathway selected by hair follicle stem cells (HFSC) is largely determined by local microenvironmental signals. In this study, human hair follicle stem cells were treated with Notch signaling blocker to explore a new approach to modu...