This paper reports rational engineering of Trypanosoma rangeli sialidase to develop an effective enzyme for a potentially important type of reactivity: production of sialylated prebiotic glycans. The Trypanosoma cruzi trans-sialidase and the homologous T. rangeli sialidase has previously been used to investigate the structural requirements for trans-sialidase activity. We observed that the T. c...

Lentil (Lens culinaris Medik.) is a nutritious food and a staple for millions of people. Not only are lentils a good source of energy, they also contain a range of micronutrients and prebiotic carbohydrates. Kale (Brassica oleracea v. acephala) has been considered as a health food, but its full range of benefits and composition has not been extensively studied. Recent studies suggest that foods...

Understanding prebiotic nucleotide synthesis is a long standing challenge thought to be essential to elucidating the origins of life on Earth. Recently, remarkable progress has been made, but to date all proposed syntheses account separately for the pyrimidine and purine ribonucleotides; no divergent synthesis from common precursors has been proposed. Moreover, the prebiotic syntheses of pyrimi...

background: nutritional strategies targeting improvement of poultry performance and disease prevention are currently being developed and in this respect the dietary intake of spiced essential oils and pre-biotics in raising broilers is receiving attention. objectives: this study was conducted to compare the effects of diet containing ginger essential oils (geo) and mannan-oligosaccharide (mos) ...

the aim of the present study was to investigate the possibility of improvingproductive performance and immunity of growing japanese quailreared during summer in egypt by supplementing the diets with organic zinc (bioplex zinc) and prebiotic (mannan oligosaccharides). diets were a basal diet or the basal diet supplemented with 20 mg bioplex zinc (3.0 mg zn) (zn1), 40 mg bioplex zinc (6.0 mg zn) ...

The poor reactivity of insoluble phosphates, such as apatite-group minerals, has been a long-appreciated obstacle for proposed models of prebiotic organophosphate formation. This obstacle presents a significant challenge to the nascent development of an RNA world and other models for the origins of life on Earth. Herein, we demonstrate that a scenario based on the formation of a urea/ammonium f...

Conceiving the process of biogenesis as the evolutionary development of highly dynamic and integrated protocell populations provides the most appropriate framework to address the difficult problem of how prebiotic chemistry bridged the gap to full-fledged living organisms on the early Earth. In this contribution we briefly discuss the implications of taking dynamic, functionally integrated prot...

OBJECTIVE To systematically review randomized controlled trials evaluating the efficacy and safety of prebiotic supplementation in full-term neonates. DATA SOURCES Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, and CINAHL databases and proceedings of relevant conferences. STUDY SELECTION Eleven of 24 identified trials (n = 1459) were eligible for inclusion. Intervention Tr...

AIM The aim was to investigate the effects of dietary supplementations of prebiotic, probiotic, and synbiotic on growth performance and carcass characteristics of broiler chickens. MATERIALS AND METHODS A total of 360 1-day-old Vencobb broiler chickens of either sex were randomly assigned to four dietary treatments each consisting of three replicates and each replicate having 30 birds for 6 w...