Extracellular signals are captured and transmitted by signaling proteins inside a cell. An important type of cellular responses to the signals is the cell fate decision, e.g., apoptosis. However, the underlying mechanisms of cell fate regulation are still unclear, thus comprehensive and detailed kinetic models are not yet available. Alternatively, data-driven models are promising to bridge sign...

The super-knock poses new challenges for further increasing the power density of spark ignition (SI) engines. critical factors and mechanism connecting regarding occurrence are still unclear. Misfire is a common phenomenon in SI engines that mixture cylinder not ignited normally, which often caused by plug failure. However, effect misfire on engine combustion has been paid enough attention to, ...

Knock twice before invading eisseria meningitidis , also known as meningococcus, is a pathogen with a nasty habit of forcing normally nonphagocytic endothelial cells to engulf it, allowing the bacterium to penetrate cellular barriers. Hoffmann et al. now demonstrate on page 133 that N. meningitidis activates two distinct signaling pathways in host cells to cause actin cytoskeleton reorganizatio...

A knock-in American option under a trigger clause is an option contract in which the option holder receives an American option conditional on the underlying stock price breaching a certain trigger level (also called barrier level). We present analytic valuation formulas for knock-in American options under the Black-Scholes pricing framework. The price formulas possess different analytic represe...