OBJECTIVES/HYPOTHESIS We investigated how study design affects the rate of recovery in Bell's palsy. STUDY DESIGN Prospective, randomized, double-blind, placebo-controlled, multicenter trial. METHODS Data were extracted from the Scandinavian Bell's palsy study, which included 829 patients. The study design was factorial; 416 patients given prednisolone, 413 not given prednisolone, 413 patie...

The addition of phenobarbitone in therapeutic dosage to the drug regimen of prednisolone-treated subjects with rheumatoid arthritis produced measurable deterioration in the clinical status of the patients associated with a more rapid clearance of prednisolone from plasma. It is considered that phenobarbitone induced the hepatic metabolism of prednisolone, effectively reducing the steady state p...

Treatment of ulcerative colitis with betamethasone phosphate enemas was found to cause suppression of the adrenal cortex, so that absorption of betamethasone from the rectum can be inferred; no suppression occurred in similar patients treated with prednisolone phosphate enemas (Matts, Wharton, Kelleher, and Walters, 1963). In order to determine whether any rectal absorption of prednisolone does...

BACKGROUND Although glucocorticoids are widely used in the treatment of patients with early rheumatoid arthritis, the best dosage of glucocorticoids with regards to efficacy and safety is not known.The aim of the study 'Comparison of the efficacy and safety of two starting dosages of prednisolone in early active rheumatoid arthritis' (CORRA) is to compare two standard glucocorticoid starting do...

BACKGROUND AND AIMS Endoscopic submucosal dissection (ESD) was developed in Japan and has been performed on many patients with early stage esophageal cancer; however quality of life in patients with postoperative stricture is drastically decreased and repeat, periodic endoscopic balloon dilatation (EBD) is usually required over long periods. In this study, we evaluate the efficacy of short peri...

A previous trial showed that treatment of children with severe IgA nephropathy (IgAN) using prednisolone, azathioprine, heparin-warfarin, and dipyridamole for 2 yr early in the course of disease reduced the severity of immunologic renal injury and prevented any increase in the percentage of sclerosed glomeruli. This study compared the effects of prednisolone, azathioprine, warfarin, and dipyrid...

The lung is, more than other solid organs, susceptible for ischemia reperfusion injury after orthotopic transplantation. Corticosteroids are known to potently suppress pro-inflammatory processes when given in the post-operative setting or during rejection episodes. Whereas their use has been approved for these clinical indications, there is no study investigating its potential as a preservation...

Idiopathic nephrotic syndrome is the most common type of nephrotic syndrome in children and is often associated with life threatening bacterial infections. While the majority of children respond to prednisolone, most have one or more relapses. In children with significant adverse effects of prednisolone, corticosteroid sparing agents may be required. A kidney biopsy is required to guide therapy...

a 56-year-old woman came in with abdominal pain, nausea, vomiting, fever, 15 kg weight loss and accelerated asthma for which she had used zafirlukast and a high dose of prednisolone. during taper down of her prednisolone, her condition deteriorated. she developed generalized wheezing, diffuse abdominal pain, and left foot drop. lab examination revealed eosinophilia, elevated red cell sedimentat...