objective: the aim of this study was to investigate the effect of pre-treatment with curcumin on metabolic changes induced by two different pathophysiological mechanisms in rats (fructose diet and streptozotocin (stz)-induced diabetes mellitus). materials and methods: five groups with 10 rats per group were investigated: control group (healthy rats), fructose diet groups without any pre-treatme...

background: hypertension is considered an independent risk factor for cardiovascular mortality in diabetic patients. the present study was designed to determine the role of gamma amino butyric acid b (gabab) receptor and l-arginine (l-arg) in gaba-induced vasorelaxation in normal and streptozotocin-induced diabetic rat vessels. methods: diabetes was induced by a single i.p. injection of strepto...

introduction: the present study used a histological evaluation method to examine the effects of pentoxifylline (ptx) on healing an experimentally-induced pressure sore in a rat model. materials and methods: there were 36 adult male rats used in this study. under general anesthesia and sterile conditions, we used forceps to create one pressure sore on each rat. a double layer of folded skin from...