We propose a virtual clinical trial for assessing the safety and efficacy of closed-loop diabetes treatments prior to an actual trial. Such trials enable rapid risk-free pretrial testing algorithms, they can be used compare different treatment variations large diverse populations. The participants are represented by multiple mathematical models, consisting stochastic differential equations, we ...

In 1997, U.S. law enforcement agencies made some 2.8 million arrests of persons under age 18. With the growth of referrals for serious and violent offenses, the demands on the limited resources of juvenile courts are greater than ever. To help States meet those demands, the Juvenile Accountability Incentive Block Grants (JAIBG) program provides Federal funds to increase the number of juvenile c...

The private value of lawsuits is based on plaintiffs’ expected recovery at trial compared to their filing costs, whereas the social value consists of the incentives suits create for injurers to invest in accident avoidance. Generally, there is no relationship between these two values: there may be either too many or too few suits from a social perspective. Thus, there is scope for corrective me...

In an era in which extensive judicial emphasis has been placed on "due process of law" in criminal proceedings, both in the federal courts and in the state courts, Dr. Szasz's book serves as a jarring reminder that in at least one vital area of the concept of due process, much remains to be done. The emerging definition of due process has enunciated the rights guaranteed the individual by the F...

OBJECTIVE To develop an empirically based framework of the aspects of randomised controlled trials addressed by qualitative research. DESIGN Systematic mapping review of qualitative research undertaken with randomised controlled trials and published in peer-reviewed journals. DATA SOURCES MEDLINE, PreMEDLINE, EMBASE, the Cochrane Library, Health Technology Assessment, PsycINFO, CINAHL, Brit...

INTRODUCTION The safety and efficacy of liraglutide in combination with an oral antidiabetic drug (OAD) compared with combination of two OADs were assessed in Japanese patients with type 2 diabetes. MATERIALS AND METHODS This was a 52-week, open-label, parallel-group trial in which patients whose type 2 diabetes was inadequately controlled with a single OAD (glinide, metformin, α-glucosidase ...

in the present study, floating drug delivery beads (fdds) were prepared with sodium alginate/ starch blend as a matrix, sodium hydrogen carbonate as a pore forming agent, methyl cellulose as a binder and barium chloride solution as a hardening agent. in order to prepare the beads with different porosity and morphology the ratio between pore forming agent to polymer blend and ratio of the consti...

Background Optimizing care continuum entry interventions is key to ending the HIV epidemic. Offering screening populations in emergency departments (EDs) a strategy that has been demonstrated be effective. Analyzing patient and provider perceptions of such can help identify implementation facilitators barriers. Objectives The aim this study was investigate acceptability offering nurse-driven ba...