INTRODUCTION Ranibizumab is an inhibitor of vascular endothelial growth factor-A (anti-VEGF) approved for the treatment of neovascular age-related macular degeneration (nAMD). The treat and extend (T&E) regimen can potentially reduce the burden of clinic visits compared with a pro re nata (PRN) regimen. Retrospective, interim analyses of clinical effectiveness, treatment and resource use patter...

BACKGROUND We conducted a meta-analysis of randomized trials of ranibizumab for age-related macular degeneration (AMD) to elucidate systemic vascular risk. CLINICAL RELEVANCE Although intravitreal vascular endothelial growth factor inhibitors are widely used to treat AMD, whether they produce systemic adverse effects remains uncertain. METHODS We searched MEDLINE, EMBASE, and Cochrane Centr...

In practice, a GPS receiver must first replicate the PRN code that is transmitted by the SV being acquired by the receiver; then it must shift the phase of the replica code until it correlates with the SV PRN code. When cross-correlating the transmitted PRN code with a replica code, the same correlation properties occur that occurs for the mathematical autocorrelation process for a given PRN co...

background patient-controlled analgesia is used for both labor and postoperative analgesia. objectives this study aimed to assess user satisfaction and functionality of two ambulatory, electronic patient controlled analgesia devices, the gemstar pump hospira inc., illinois, usa) and the ambit ambulatory infusion therapy pump (sorenson medical products, utah, usa). patients and methods it was a ...

The purpose of this study was to examine the disposition of diphenhydramine (DPHM) across the ovine blood-brain barrier (BBB). In six adult sheep, we characterized the central nervous system (CNS) pharmacokinetics of DPHM in brain extracellular fluid (ECF) and cerebrospinal fluid (CSF) using microdialysis in two experiments. In the first experiment, DPHM was administered via a five-step i.v. in...

The premature primate exposed to hyperoxia provides a useful model of bronchopulmonary dysplasia. A critical target in hyperoxic injury is the mitochondrial matrix enzyme aconitase. We hypothesized that this enzyme's activity would decline in the premature baboon lung during exposure to hyperoxia. Total aconitase activity was significantly decreased in the lungs of premature baboons of 140 days...

The calibration of correlation radiometers, and particularly aperture synthesis interferometric radiometers, is a critical issue to ensure their performance. Current calibration techniques are based on the measurement of the cross-correlation of receivers' outputs when injecting noise from a common noise source requiring a very stable distribution network. For large interferometric radiometers ...

background: the aim of this study is comparing acth changes in epidural and intravenous analgesia technique after lower limb orthopedic surgery.methods: in a randomized clinical trial in hazrat rasool  akram hospital during 1387-88 , 60 patients candidate for surgery on the lower extremities were randomly allocated to receive either postoperative analgesia  with epidural analgesia (pcea) or iv ...

The Packet Radio Network (PRN) is an attractive architecture to support wireless data communication. The code assignment problem in PRN is a classical problem that has been extensively studied. However, in this paper we observe that the power control issue has been ignored by most works, but may have significant impact on PRN’s performance. Given a set of PRN stations, the network topology can ...