BACKGROUND Sepsis is a deadly immunological disorder and its pathophysiology is still poorly understood. We aimed to determine if specific pro-inflammatory and anti-inflammatory cytokines can be used as diagnostic and therapeutic targets for sepsis. MATERIALS AND METHODS Recent publications in the MEDLINE database were searched for articles regarding the clinical significance of inflammatory ...

This study investigated the function of a chloride channel blocker, DIDS. Both in vitro and in vivo studies found that DIDS significantly inhibits lipopolysaccharide (LPS)-induced release of proin flammatory cytokines. Here, we show that DIDS inhibits LPS-induced inflammation, as shown by downregulation of inflammatory cytokines via inhibition of the TLR4/NF-κB pathway. Furthermore, we show tha...

Preeclampsia is a pregnancy disease characterized by hypertension and proteinuria. Among several disorders, the imbalance of inflammatory cytokines and the alteration of vitamin D metabolism have been reported in preeclampsia. The effects of calcitriol upon inflammatory cytokines has been demonstrated. In healthy pregnant women there is a shift toward a Th2 cytokine profile, which is necessary ...

The emerging SARS-CoV-2 (2019-nCoV) is still following the increasing trend of infection worldwide with an elderly male predominance. Studies reported that majority patients COVID-19 suffer from severe testosterone deficiency and are likely to die coronavirus mainly due a less effective immune response high level pro-inflammatory cytokines, condition called cytokine storm. Testosterone (a stero...

Streptococcus suis 2 is an important swine pathogen and an emergent zoonotic pathogen. Excessive inflammation caused by S. suis is responsible for the high levels of early mortality observed in septic shock-like syndrome cases. However, the mechanisms through which S. suis 2 (SS2) causes excessive inflammation remain unclear. Thus, this study aimed to identify novel pro-inflammatory mediators t...

Abstract Background Patients with intra-articular fractures tend to develop post-traumatic osteoarthritis (PTOA). The initial inflammatory response elevation of cytokines following joint trauma might be responsible for triggering cartilage catabolism and degradation. We aimed identify quantify cytokine levels in fractured healthy knee joints the correlation these clinical outcomes. Methods In t...

introduction: cytokines are a large group of proteins play a key role in inflammation. down-regulation of pro-inflammatory cytokines has beneficial effect on heart function. propranolol, as a non selective beta-adrenergic blocker, has been extensively used for treatment of many cardiovascular problems such as arrhythmias and heart malfunction. in addition anti-inflammatory effects of propranolo...

Propolis is known for its immunomodulatory properties. We investigated the effects of three recently developed propolis extract formulations: polar fraction (PPF), soluble dry (PSDE), and microencapsulated (MPE), some their components, on pro- anti-inflammatory cytokine production in a macrophage model. Bone marrow cell-derived macrophages (BMDM) cell culture were E. coli lipopolysaccharide (50...

epilepsy is one of the most common neurologic diseases around the world and more significantly in iran (0.4-1 % worldwide and 5% in iran). almost one-third of these patients suffer from treatment-resistant epilepsy, which reduces their quality of life by recurring epileptic onsets. there are different approaches for the treatment of both treatment-resistant and treatment-nonresistant epilepsy, ...

The process of spontaneous abortion involves a complex mechanism with various cytokines, growth factors, and hormones during the pregnancy. However, the mechanism underlying spontaneous abortion by pro- and anti-inflammatory cytokines in the serum during the pregnancy is not fully understood. Therefore, the purpose of this study was to examine the relationship between the serum levels of pro- a...