As early as the 18th century, physicians noticed that some cancer patients went into remission after developing fevers from infections. This led to the idea that the immune system, which protects from infection, might also fight cancer. What is now known as “immunotherapy” is a treatment that targets the immune system to recognize and eradicate cancer cells. Modern immunotherapy has focused on ...

Bromodomain and extra-terminal domain inhibitors target bromodomain-containing proteins are currently being evaluated as anti-cancer agents. In this study, we found that bromodomain extraterminal inhibitor OTX015 can effectively inhibit the proliferation of hepatocellular carcinoma cells promote apoptosis cells. At same time, anticancer effect is better than JQ1, a similar inhibitor. addition, ...

To explore the function of C-X-C motif chemokine ligand as a prospective early biomarker for recurrent glioblastoma multiforme is objective study. The differentially expressed genes patients were systematically explored; gene ontology and Kyoto encyclopedia genomes enrichment analysis potential hub was established; functional network developed by protein-protein interaction method. cell line U2...

Programmed death 1 (PD-1) and its ligands, PD-L1 and PD-L2, play an important role in the maintenance of peripheral tolerance. We explored the role of PD-1 ligands in regulating graft-versus-host disease (GVHD). Both PD-L1 and PD-L2 expression were upregulated in the spleen, liver, colon, and ileum of GVHD mice. Whereas PD-L2 expression was limited to hematopoietic cells, hematopoietic and endo...