BACKGROUND Progressive Hemifacial Atrophy (PHA) is an acquired, typically unilateral, facial distortion with unknown etiology. The true incidence of this disorder has not been reported, but it is often regarded as a subtype of localized scleroderma. Historically, a debate existed whether PHA is a form of linear scleroderma, called morphea en coup de sabre (ECDS), or whether these conditions are...

PURPOSE To clone and characterize the canine RPE65 cDNA from normal dog, examine for mutations, and establish if the mutation identified in Swedish briard dogs with retinal dystrophy is present in dogs of the same breed that originated from the United States and other countries, and are affected with congenital stationary night blindness. METHODS Fifteen briard dogs were studied, of which 10 ...

Diabetic Retinopathy (DR) is a progressive asymptomatic neuro-vascular complication of diabetes that triggers irreversible retinal damage [...]

: This narrative review highlights routes of ocular drug delivery for age-related macular degeneration (AMD). AMD is the leading cause irreversible blindness in industrialized countries and accounts 8.7% worldwide. Advanced can be classified into two subtypes: late-stage dry [known as geographic atrophy (GA)] neovascular (nAMD). GA often bilateral results from progressive loss photoreceptors ar...

Progressive Hemifacial Atrophy, also known as Parry-Romberg Syndrome, is an uncommon degenerative and poorly understood condition. It is characterized by a slow and progressive atrophy affecting one side of the face. The incidence and the cause of this alteration is unknown. A cerebral disturbance of fat metabolism has been proposed as a primary cause. This can be the result of a trophic malfor...

purpose: to evaluate the correlation between retinal nerve fiber layer (nfl) thickness and visual field parameters in patients with optic atrophy. methods: this study was performed on 35 eyes of 28 patients with optic atrophy. nfl thickness was measured by optic coherence tomography (oct) and visual field analysis was performed by humphrey perimetry. the correlation between nfl thickness and vi...

PURPOSE To evaluate which morphologic features of the optic disc are predictive factors for the development or progression of visual field loss in chronic open-angle glaucoma. METHODS The prospective observational clinical study included 763 eyes of 416 white subjects with ocular hypertension and chronic open-angle glaucoma. During the follow-up time (mean, 67.4 months; median, 65.1; range, 6...

Optical coherence tomography (OCT) is considered a key research tool to monitor neurodegenerative processes in CNS disorders. This particularly applicable multiple sclerosis (MS), which retinal changes (peripapillary nerve fiber layer and ganglion cell–inner plexiform [GCIPL] thicknesses) tend reflect MRI markers of damage atrophy, especially eyes not affected by previous optic neuritis.1

A congenital anomaly, optic nerve pit is often associated with serous retinal detachment involving macula. Long standing serous detachment leads to outer retinal atrophy and decrease in visual sensitivity. Recently, spectral-domain optical coherence tomography (OCT) has been reported to demonstrate a communication between the optic nerve sheath and the subretinal space. Vitreous cavity is propo...