Neoplasms of histiocytic and dendritic cells are rare disorders of the lymph node and soft tissues. Because of this rarity, the corresponding biology, prognosis and terminologies are still being better defined and hence historically, these disorders pose clinical and diagnostic challenges. These disorders include Langerhans cell histiocytosis (LCH), histiocytic sarcoma (HS), follicular dendriti...

A 40-year-old male presented with a single generalized tonic-clonic seizure. MRI revealed an enhancing, dural-based, left lateral sphenoid wing lesion suggestive of a meningioma. At microsurgical excision, the lesion was firm and relatively avascular. The histopathological report revealed S-100 positive histiocytic proliferation with lymphophagocytosis (emperipolesis) characteristic of the Rosa...

Histiocytic necrotizing lymphadenitis (HNL) is a unique form of self-limiting lymphadenitis with an unknown cause. The majority of cases resolve within several months and the disease has a low recurrence rate of 3-4%. In the present study, a prolonged recurrent case of HNL was reported. A 44-year-old female developed recurrent HNL with generalized lymphadenopathy 14 years after the original epi...

Langerhans cell histiocytosis is a rare histiocytic disorder and has been diagnosed in all age groups, but is most common in children. This disease is very rare in adults. We presented a patient who was 62 years old man diagnosed langerhans cell histiocytosis.

the remainder were histiocytic. The sex incidence of lymphomas was equal, but lymphomas of lymphocytic type were found only in females and occurred late in life. The anatomic pattern of lymphoma metastasis resembled that for other types of cancer with direct extension, regional, and distant metastasis; there were only 2 cases with leukemia-like disease. The possible significance of Peyer's patc...

Kikuchi's disease is a benign condition that occurs in women. A young woman presented to the hospital with fevers and cervical lymphadenopathy. Infectious work-up was negative except for streptococcus pharyngitis. Imaging studies revealed the presence of diffuse cervical and axillary lymphadenopathy. The fevers persisted and she underwent excisional cervical lymph node biopsy that revealed hist...

Kikuchi-Fujimoto disease is an idiopathic histiocytic necrotizing lymphadenitis with an autoimmune component triggered by the involvement of CD8 cytotoxic T lymphocyte due to a genetic predisposition. Cases are diagnosed more frequently in female patients, especially in young adults, in all races, more commonly in East Asia, and only isolated in Europe and America. We present the case of a 51-y...