promethazine hydrochloride, a 5-ht3 antagonist is a powerful antiemetic drug with an oral bioavailability of 25% due to extensive hepatic first pass metabolism and is extremely bitter in taste. to overcome the above draw backs, the present study was carried out to formulate and evaluate fast dissolving taste masked wafers of promethazine hydrochloride for sublingual administration. taste maskin...

The use of antihistamine therapy in children for the management upper respiratory tract infections remains a topic debate. In this study, we focused on evaluating effectiveness promethazine (Phenergan), first-generation H1 receptor antagonist and sedative, addressing preoperative intra-operative sequelae cleft surgeries. A single-centered, parallel, randomized, double-blinded controlled clinica...