The objective of the present study was to investigate the use of propranolol-magnesium aluminium silicate intercalated complexes as drug reservoirs in hydroxypropylmethylcellulose tablets. The matrix tablets containing the complexes were prepared and characterised with respect to propranolol release and were subsequently compared with those loading propranolol or a propranolol-magnesium alumini...

Twenty-four patients with stable angina were evaluated in a 14 week crossover trial. A single-blind placebo period (baseline 1) was followed by two double-blind periods evaluating maximum tolerated doses of diltiazem (up to 360 mg daily) vs placebo. Over the next 1 to 4 weeks, propranolol was started and increased until clinically documented f-blockade was achieved (baseline 2). The final phase...

1. Carbohydrate and lipid metabolism and the capacity to perform prolonged submaximal physical exercise were studied in six young healthy subjects treated in a randomized double-blind fashion for 2 days with either placebo, the non-selective beta-adrenoceptor antagonist propranolol (80 mg b.i.d.) or the cardioselective agent metoprolol (100 mg b.i.d.). On day 3, 1 h after the last dose, the sub...

  Since the first report in 1977, many studies have been carried out to determine the efficacy of beta- blockers such as propranolol for the treatment of violent  and aggressive behaviour. Propranolol has also  been used in the treatment of dementia, attending- deficit disorder, schizophrenia, personality disorders, Korsakoff,s psychosis, posttraumatic stress disorder, profound mental retardat...

Levothyroxine tablet overdose, can happen in children, because of unique physical nature the tablet. Although it has a benign course, systemic symptoms overdose may manifest few children. This cannot be predicted based on dose consumed or by thyroid function tests. Propranolol and steroid used for autonomic symptoms. Delayed manifestation occur, which needs follow up. In this report, we present...

Antecedentes: los hemangiomas infantiles son tumores vasculares benignos más frecuentes en la infancia, siendo su localización habitual cabeza y el cuello, representando 50 % de las masas que afectan a glándula parótida. Debido al rápido crecimiento expansivo estas lesiones, pueden aparecer complicaciones significativas, como pérdida función del órgano o desfiguración permanente, por lo interve...

The capacity of the vasodilating drugs, minoxidil and hydralazine, for inducing renin release was characterized in rats according to chronology and dose response. Propranolol inhibition of this renin release was also characterized and related to serum levels of propranolol. Minoxidil and hydralazine (1.0 mg/kg) induced sevenfold elevations of serum renin activity. Treatment with propranolol, re...

The inhibitory effect of (+/-) propranolol 1.69 x 10(-4)-1.69 x 10(-7) mol litre-1 on normal and atypical plasma cholinesterase variants was investigated. The atypical enzyme is less sensitive to inhibition by (+/-) propranolol or either of its enantiomorphs than the usual enzyme. Propranolol 8.45 x 10(-6) mol litre-1 was used as differential inhibitor of 643 plasma samples from individuals of ...

Background The aim of the study was to investigate the effect of propranolol on systemic oxidative stress and endotoxemia in patients with liver cirrhosis and clinically significant portal hypertension evidenced by the presence of esophageal varices. Methods Fourteen patients with liver cirrhosis and esophageal varices, not previously been treated with non-selective beta-blockers (NSBB), were...

Nine patients with stable angina (group 1) underwent maximal treadmill stress testing and thallium-201 (201T1) myocardial scintigraphy after intravenous propranolol hydrochloride, and after placebo. Though seven of the nine patients exercised longer after propranolol than after placebo, this difference did not reach statistical significance. Propranolol, however, significantly reduced the mean ...