These experiments investigate the decomposition mechanisms of geminal dinitro energetic materials by photolytically generating two key intermediates: 2-nitropropene and 2-nitro-2-propyl radicals. To characterize the unimolecular dissociation of each intermediate, we form them under collision-free conditions using the photodissociation of 2-bromo-2-nitropropane; the intermediates are formed at h...

formation of the active alkylating species, i.e., the alkyldiazonium ion, has been described by Shapiro (3), and the alkylation of DNA has been described by Lawley and Thatcher (1). In order, however, to compare the effects of higher alkyl homologs on the properties of the DNA, the kinetics of formation of the active alkylating species are required. The TV-methyl, TV-ethyl,TV-propyl, and TV-but...

In the present research, silica bonded n-propyl-1,3,5-triazine-2,4,6-triamine (SPTT) was synthesized by direct incorporation of chloropropyl groups through co-condensation of tetraethyl orthosilicate (TEOS) and 3-chloropropyl trimethoxysilane (CPTMS) and subsequent grafting the melamine onto the propyl groups via simple nucleophilic substitution reaction. The catalyst has been characterized by ...

The discovery of the antifertility activity of gossypol led scientists and researchers to the development of compounds with antifertility activity that can be used as male contraceptives. These studies resulted in discovery of the antifertility activity of several classes of compounds which have been reported in the literature. This article deals with the synthesis of four new analogues of pyri...

the discovery of the antifertility activity of gossypol led scientists and researchers to the development of compounds with antifertility activity that can be used as male contraceptives. these studies resulted in discovery of the antifertility activity of several classes of compounds which have been reported in the literature. this article deals with the synthesis of four new analogues of pyri...

The structures of four selenium analogues of the antithyroid drug 6-n-propyl-2-thiouracil [systematic name: 2,3-dihydro-6-n-propyl-2-thioxopyrimidin-4(1H)-one], namely 6-methyl-2-selenouracil, C(5)H(6)N(2)OSe (1), 6-ethyl-2-selenouracil, C(6)H(8)N(2)OSe (2), 6-n-propyl-2-selenouracil, C(7)H(10)N(2)OSe (3), and 6-isopropyl-2-selenouracil, C(7)H(10)N(2)OSe (4), are described, along with that of t...

The effects of hypothyroidism for a short period of postnatal life on the induction of persistent estrus by androgen were investigated in female rats of 10 and 13 days of age. Hypothyroidal new born rats produced by feeding propyl thiouracil (PTU) to the mother rats, were more succeptible to the persistent-estrus inductive influence of androgen than normal and thyroxine-therapied hypothyroidal ...

In continuing studies of drugs against Mycobacterium leprae in mice we have tested the following compounds: lincomycin, clinimycin (7( S ) -chloro-7 -deoxylincomycin, clindamycin) , U-24729A (4' -pentylN -demethyl-7 -chlorolincomycin), amicetin, phosphonomycin, ABT-29666 (1-{3-[ 4-(pchlorophenyl-azo )-5, 6, 7, 8-tetrahydro-1naphthylamino] propyl} piperidine), ABT38396 (1{3-[ 4-( 6-methoxy-3-pyr...

A variety of in homogeneously broadened optical and infrared transitions in solids display persistent spectral holes when irradiated with a narrowband laser. In the case of photochemical hole burning, absorption decreases at the laser frequency because the center undergoes an internal chemical change such as bond rearrangement or ionization. 1-3 Nonphotochemical hole burning is thought to occur...

The ability of 19 structural analogs of propyl gallate to inhibit purified soybean seed (Glycine max [L.] Merr. var. Ransom) lipoxygenase-2 (EC 1.13.11.12) was determined. The results indicate that the o-dihydroxy and not the ester function of propyl gallate is essential for inhibition of lipoxygenase. Catechol thus represents the minimum inhibitory structure. Among those compounds possessing a...