Abstract Background Hypertrophy is a critical process for chondrocyte differentiation and maturation during endochondral ossification, which responsible the formation of long bone postnatal longitudinal growth. Increasing evidence suggests that melatonin, an indole hormone, plays pivotal role in chondrogenesis. However, little known about effects melatonin on terminal chondrocytes. Methods Mese...

The S-band Phased Array Radar (PAR) at the National Weather Radar Testbed (NWRT) in Norman, Oklahoma can adaptively scan multiple regions of interest and provide rapidly updated weather observations by electronically beam steering. This capability allows providing fast updates of weather information with high statistical accuracy with scanning strategy termed beam multiplexing ([Yu et al., 2007...

Olfactory receptors (OR), responsible for detection of odor molecules, belong to the largest family of genes and are highly polymorphic in nature having distinct polymorphisms associated with specific regions around the globe. Since there are no reports on the presence of copy number variations in OR repertoire of Indian population, the present investigation in 43 Indians along with 270 HapMap ...

The array format has revolutionised biomedical experimentation and diagnostics, enabling ordered high-throughput analysis. During the past decade, classic solid phase substrates, such as microtitre plates, membrane filters and microscopic slides, were turned into high-density, chip-like structures. The concept of the arrayed library was central to this development which now extends from DNA to ...

In the paper the programmable logic array (PLA) topological optimization problem is dealt with using folding techniques. A PLA folding algorithm based on the method of simulated annealing is presented. A simulated-annealing PLA folding algorithm is presented for multiple unconstrained folding. Then, the algorithm is extended to handle constrained folding. In this way, simple folding is consider...

  Background:The dynamic binding capacity (DBC) of a chromatography matrix in protein purification is the amount of the total protein absorbed into the matrix, before occurrence of a significant break in the breakthrough curve. Optimization of the process criteria for maximum DBC avoids extra process scale-up and reduces ...

background: leishmania, needs to detoxify the macrophage derived potent peroxides (h2o2). tryparedoxin path­way contains tryparedoxin peroxidase (tsa or tryp). the aim of the study was to detect the full-length gene se­quence and its encoded protein of the lmtryp6 gene (eu251502), and comparison the gene sequence with lmtryp6 (lmjf15.1140), another previously reported member of this gene family...

Recent discovery of the copy number variation (CNV) in normal individuals has widened our understanding of genomic variation. However, most of the reported CNVs have been identified in Caucasians, which may not be directly applicable to people of different ethnicities. To profile CNV in East-Asian population, we screened CNVs in 3578 healthy, unrelated Korean individuals, using the Affymetrix G...

In this work, we present a methodological approach to analyze an enhanced dielectrophoresis (DEP) system from both a circuit analysis and electrothermal view points. In our developed model, we have taken into account various phenomena and constraints such as voltage degradation (due to the presence of the protecting oxide layer), oxide breakdown, instrumentation limitations, and thermal effects...