xue bing yan department of infectious diseases, the first affiliated hospital of xuzhou medical college, china +51-685802180, [email protected]; department of infectious diseases, the first affiliated hospital of xuzhou medical college, china +51-685802180, [email protected] zhi chen institute of infectious diseases, the first affiliated hospital, college of medical science, key laboratory of ministry health, zhejiang university, china christian brechot inserm, u785, university paris sud, centre hepato-biliaire, france