SARS-CoV-2 remains life-threatening human pathogen witnessed in the present world. Purpose. The key objective of this research was to incorporate a bioinformatics technique forecast molecular docking ACE2-associated SARS-CoVs nucleocapsid protein. Methods. Different tools were used study order compare chemical structures with their biological behaviour at levels atoms and ligand-binding affinit...

We describe a proteomics method for determining the subcellular localization of membrane proteins. Organelles are partially separated using centrifugation through self-generating density gradients. Proteins from each organelle co-fractionate and therefore exhibit similar distributions in the gradient. Protein distributions can be determined through a series of pair-wise comparisons of gradient ...

The plant based MYB transcription factors have been extensively studied for structural and functional characterization. protein is known to perform several molecular biological processes including regulation of gene expression. In the current study, we identified characterized a R2R3 type TF (WsMYB44) pertaining root specific library from Withania somnifera. phylogenetic studies sequence reveal...

Background: Whether AGR2 promotes adenocarcinoma growth as a secreted or ER localized protein is not known. Results: A unique C-terminal motif, KTEL, is required for AGR2 ER localization and function. Conclusions: Not all ER localization motifs are interchangeable. Significance: Specific ER localization signals may be required for protein function. AGR2's tumor promoting effects are mediated fr...