Abstract Sorghum is highly tolerant to alkaline stress, but the underlying mechanisms are not well understood. Here, based on genotypic difference in tolerance of sorghum, it was found that AT1 (Alkaline 1) encoding a G protein involved through negatively modulating phosphorylation level PIP2, an aquaporin with transport activity for H 2 O . Knockout releases its inhibition thereby resulting in...

Abstract The inflammasome comprised of an innate immune receptor/sensor, pro-caspase-1, and a common adaptor molecule, ASC (apoptotic speck-containing protein with CARD) initiates defense inflammatory response by activating caspase-1 pyroptotic cell death in myeloid cells. Consistent their pro-inflammatory function, caspase-1, NLRP3 were known to exacerbate autoimmunity during experimental auto...

The bacterial phosphoenolpyruvate (PEP):carbohydrate phosphotransferase system (PTS) carries out both catalytic and regulatory functions. It catalyzes the transport and phosphorylation of a variety of sugars and sugar derivatives but also carries out numerous regulatory functions related to carbon, nitrogen, and phosphate metabolism, to chemotaxis, to potassium transport, and to the virulence o...

Corticosterone (CORT)-induced oxidative stress and neurotoxicity can cause neuronal dysfunction mental disorders. In the present study, we investigated effects mechanism of HP-20 resin fraction water extract Vaccinium bracteatum leaves (NET-D1602) its bioactive compound p-coumaric acid on cell damage in SH-SY5Y cells primary culture rat cortical cells. NET-D1602 significantly improved viability...

Phosphorylation of H2AX is believed to be associated with the repair of damaged DNA. Recent findings suggest a novel function of H2AX in cellular apoptosis. Specifically, it was shown that ultraviolet A-activated JNK phosphorylates H2AX to regulate apoptosis. Here we show that serum starvation induces H2AX phosphorylation and apoptosis independent of the JNK pathway. Serum starvation induced p3...

Prostate cancer is hormone-dependent and the androgen receptor (AR) involved in its development. AR a transcription factor that activated by ligand binding, result translocation into nucleus, where it initiates gene transcription. In an inactive state cytoplasm exists as complex with heat shock protein 90 (HSP90) some other proteins. When agonist binds, conformational change occurs, resulting H...