The family of Solanaceae includes about 90 genera and over 2000 speeies. Among them a great number of important plants has agronomie and phannaeeutieal uses. They contai n alkaloids and triterpenoids as main aetive eonstituents. Among the last eompounds, it is important to eonsider a group of eompounds speeifie to Salanaceae, the withanolides, present in partieular in Withania samnifera. W samn...

We report on the antimicrobial activity of a cream formulation of silver nanoparticles (AgNPs), biosynthesized using Withania somnifera extract. Aqueous extracts of leaves promoted efficient green synthesis of AgNPs compared to fruits and root extracts of W. somnifera. Biosynthesized AgNPs were characterized for their size and shape by physical-chemical techniques such as UV-visible spectroscop...

Aims: The present research was done to evaluate the antioxidant activity of aqueous extract Withania somnifera (Ashwagandha) in equine. Herbal antioxidants have gained popularity due their potency and safety, oxidative stress is a condition that more prevalent horses performing physical activities.
 Methods: Twenty clinically healthy were selected equally divided into treatment control gro...

6-Hydroxydopamine (6-OHDA) is one of the most widely used rat models for Parkinson's disease. There is ample evidence in the literature that 6-OHDA elicits its toxic manifestations through oxidant stress. In the present study, we evaluated the anti-parkinsonian effects of Withania somnifera extract, which has been reported to have potent anti-oxidant, anti-peroxidative and free radical quenchin...

Background: In this open-label, randomized, balanced, two-treatment, two-sequence, two-period, crossover, single-dose oral comparative pharmacokinetics study, the pharmacokinetics, safety, and tolerability of test product ‘ashwagandha (Withania somnifera)’ root extract sustained release capsule 300 mg (Prolanza™), each containing 15 withanolides (administered dose: 2×15 mg) was compared with th...

The objective of the present study was to evaluate the antidepressant action of Withania somnifera (WS) as well as its interaction with the conventional antidepressant drugs and to delineate the possible mechanism of its antidepressant action using forced swimming model in mice. Effect of different doses of WS, fluoxetine and imipramine were studied on forced swimming test induced mean immobili...