drug therapy is a complex and important process and because of the importance of drug interactions, especially in in-patients, accompanying problems and obstacles would exist as a result of concomitant use of drugs in these patients. for this purpose 3130 prescription order forms from bou-ali hospital were collected and all potential drug interactions presentwere extracted and evaluated in term...

Objectives: The prevalence of many Class III CFTR mutations are present in at least one allele approximately 10% the CF population. Type do not impact surface quantity cell but cause defects channel gating. introduction VX-770 has resulted treated patients having a lower CF-related complications and better-preserved lung function. is currently only potentiator approved for use patients. Despite...

Synapse-associated protein 102 (SAP102) is a scaffolding protein abundantly expressed early in development that mediates glutamate receptor trafficking during synaptogenesis. Mutations in human SAP102 have been reported to cause intellectual disability, which is consistent with its important role during early postnatal development. SAP102 contains PDZ, SH3 and guanylate kinase (GK)-like domains...

The in vitro pull-down assay is a well-established method to confirm direct binding in protein-protein interactions that was inferred from other interaction assays, such as two-hybrid analysis (1). The assay is usually carried out using glutathione-S-transferasetagged or His-tagged fusion proteins as the pull-down drivers and in vitro-translated 35S-labeled proteins as probes to detect interact...

We describe two complementary methods to quantify the degree of burial of ligand and/or ligand binding site (LBS) in a protein-ligand complex, namely, the ‘cutting plane’ (CP) and the ‘tangent sphere’ (TS) methods. To construct the CP and TS, two centroids are required: the protein molecular centroid (global centroid, GC), and the LBS centroid (local centroid, LC). The CP is defined as the plan...

Synapse-associated protein 102 (SAP102) is a scaffolding protein abundantly expressed early in development that mediates glutamate receptor trafficking during synaptogenesis. Mutations in human SAP102 have been reported to cause intellectual disability, which is consistent with its important role during early postnatal development. SAP102 contains PDZ, SH3 and guanylate kinase (GK)-like domains...

multi-environment trials play a significant role in selecting the best cultivars to be used at different locations. the objective of this study was to identify grain and forage yields stability of grass pea advanced lines across different locations. the 14 advanced lines of grass pea, developed by the international center for agricultural research in dry areas (icarda), were tested at three dif...